Personal profile
Research interests
Dr. Alakesh Bera is a biomedical scientist specializing in biochemistry, biophysics, and translational medicine, with over fifteen years of research experience spanning academia, government, and clinical research environments. His research focuses on the molecular mechanisms underlying neuromuscular disorders and their broader implications in human disease, particularly malignant hyperthermia, Duchenne muscular dystrophy, and muscle-related dysfunction associated with endocrine and genetic conditions. At the Uniformed Services University of the Health Sciences (USUHS), he directs the Malignant Hyperthermia Core Laboratory and leads interdisciplinary research integrating molecular biology, genomics, proteomics, and advanced computational approaches to understand disease mechanisms and identify therapeutic targets. His work emphasizes the structure-function relationships of key proteins such as the Ryanodine Receptor (RYR1), the genetic and molecular links between neuromuscular diseases and cancer, and the development of novel diagnostic and therapeutic strategies. Dr. Bera has trained and mentored students and researchers at multiple levels and actively collaborates with national and international research institutions to translate fundamental discoveries into clinically relevant applications.
Education/Academic qualification
Biochemistry, PhD, Structural Changes of Prion Protein in the Presence of Nucleic Acids, Université d'Orléans
11 May 2003 → 26 Apr 2006
Award Date: 26 Apr 2006
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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Molecular Mechanisms of Ryanodine Receptor (RYR1) Mutations in Malignant Hyperthermia and Cancer
7/10/24 → …
Project: Research
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Biodiversity of the Bacterial and Fungal Microbiome and Associated Inflammatory Cytokine Profile in Chronic Rhinosinusitis
Yang, H. H., Simpson, C. A., Srivastava, M., Bera, A., Cappelletti, M., Suh, J. D., Wang, M. B., Beswick, D. M., Maxim, T., Basak, S. K., Srivatsan, E. S., Fischer, J. L., Jacobs, J. P. & Lee, J. T., May 2025, In: International Forum of Allergy and Rhinology. 15, 5, p. 502-512 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Blood-Based Lateral-Flow Immunoassays Dipstick Test for Damaged Mitochondrial Electron Transport Chain in Pyruvate Treated Rats with Combined Blast Exposure and Hemorrhagic Shock
Okonkwo, E., Saha, B., Sahu, G., Bera, A. & Sharma, P., Feb 2025, In: Journal of Clinical Medicine. 14, 3, 754.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Identification of Serum Biomarkers for Blast‐induced Traumatic Brain Injuries: Low vs. High‐intensity Exposure in a Rat Model
Bera, A., Subhramanian, M. & Sharma, P., 1 Jul 2025, In: In Vivo. 39, 4, p. 1840-1851 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Neoantigen-specific tumor-infiltrating lymphocytes in gastrointestinal cancers: a phase 2 trial
Lowery, F. J., Goff, S. L., Gasmi, B., Parkhurst, M. R., Ratnam, N. M., Halas, H. K., Shelton, T. E., Langhan, M. M., Bhasin, A., Dinerman, A. J., Dulemba, V., Goldlust, I. S., Gustafson, A. M., Hakim, A. A., Hitscherich, K. J., Kenney, L. M., Levy, L., Rault-Wang, J. G., Bera, A. & Ray, S. & 13 others, , Jun 2025, In: Nature Medicine. 31, 6, p. 1994-2003 10 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
Publisher Correction: Neoantigen-specific tumor-infiltrating lymphocytes in gastrointestinal cancers: a phase 2 trial (Nature Medicine, (2025), 31, 6, (1994-2003), 10.1038/s41591-025-03627-5)
Lowery, F. J., Goff, S. L., Gasmi, B., Parkhurst, M. R., Ratnam, N. M., Halas, H. K., Shelton, T. E., Langhan, M. M., Bhasin, A., Dinerman, A. J., Dulemba, V., Goldlust, I. S., Gustafson, A. M., Hakim, A. A., Hitscherich, K. J., Kenney, L. M., Levy, L., Rault-Wang, J. G., Bera, A. & Ray, S. & 13 others, , Jun 2025, In: Nature Medicine. 31, 6, p. 2072 1 p.Research output: Contribution to journal › Comment/debate
2 Scopus citations
Press/Media
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Recent Findings from Uniformed Services University of the Health Sciences Provide New Insights into Malignant Hyperthermia [Clinical and Genetic Characterization of a Novel RYR1 Variant (p.Gln474His) in Malignant Hyperthermia Susceptibility]
Vietor, R., Bera, A. & Bedocs, P.
11/02/26
1 item of Media coverage
Press/Media
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Research from Uniformed Services University of the Health Sciences Provide New Insights into Thyroid Cancer [Role of Annexin 7 (ANXA7) as a Tumor Suppressor and a Regulator of Drug Resistance in Thyroid Cancer]
Harvey Pollard, Meera Srivastava & Alakesh Bera
23/12/24
1 item of Media coverage
Press/Media