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Dr. Allison Malloy is an Associate Professor in the Department of Pediatrics at the F. Edward Hébert School of Medicine at the Uniformed Services University of the Health Sciences (USU) in Bethesda, Maryland. Dr. Malloy joined the faculty of the School of Medicine in 2013. She heads the Laboratory of Infectious Diseases and Host Defense and is a Pediatric Infectious Diseases physician at the Walter Reed National Military Medical Center (WRNMMC). Dr. Malloy teaches at the USU School of Medical, Graduate School and WRNMMC.
Dr. Malloy’s research program seeks to define the immune mechanisms that drive protection and disease in response to respiratory viral pathogens. Towards these goals, Dr. Malloy has been awarded research funding to improve understanding in early life respiratory mucosal immune responses to respiratory syncytial virus (RSV) and develop vaccine platforms to protect against infection and disease in order to preserve lung health in young children. She has also received funding to define T cell responses established or recruited by distinct influenza vaccine platforms to inform development of next generation influenza vaccine platforms. Through development of a large military longitudinal prospective cohort study, Dr. Malloy has defined the durability of T cell responses against SARS-CoV-2 infection, and the complex nature of T cells responding to infection and their association with disease severity. In 2026, Dr. Malloy was award funding to develop vaccine platforms for Lassa virus, a key pathogen lacking prevention measures for active duty military members at risk. Dr. Malloy has also supported the development and research focus a pediatric prospective clinical cohort study to address the impact of respiratory viruses on the respiratory mucosal and circulating immune response in children. The focus of her research and development of novel understanding of mucosal immunity has enable collaborations with the Vaccine Research Center (VRC), the Laboratory of Infectious Diseases, and the Mucosal Immunobiology Section with in the National Institute of Allergy and Infectious Diseases (NIAID) at the NIH, the Children’s Hospital of Philadelphia, and the Walter Reed Army Institute of Research.
Prior to joining the faculty at USU, Dr. Malloy was a clinical research fellow at the VRC with in the NIAID at NIH. She developed unique murine models to address key questions about the development of the respiratory mucosal immune response to RSV. Dr. Malloy performed her Pediatric Infectious Disease Fellowship in a joint program with the Children’s National Medical Center in Washington DC and the VRC. Prior to her fellowship, she was a resident at the Children’s Hospital of Philadelphia and earned her doctoral degree at the George Washington School of Medicine.
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Collaborations and top research areas from the last five years
Projects
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Distinct innate immune activation profiles of an mRNA-lipid nanoparticle vaccine compared to the empty lipid nanoparticle
Zelkoski, A. E., Mitre, E., Alameh, M. G. & Malloy, A. M. W., 25 Jan 2026, In: Vaccine. 71, 128061.Research output: Contribution to journal › Article › peer-review
Open Access -
Clinical Characteristics and Outcomes of Cardiac Findings in Young Persons Following SARS-CoV-2 Infection
EPICC COVID-19 Cohort Study Group, 1 Apr 2025, In: Pediatric Infectious Disease Journal. 44, 4, p. 342-345 4 p.Research output: Contribution to journal › Article › peer-review
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Patterns of restricted TCR usage following SARS-CoV-2 vaccination and severe disease
EPICC COVID-19 Cohort Study Group, 2025, In: Frontiers in Immunology. 16, 1576903.Research output: Contribution to journal › Article › peer-review
Open Access -
Pediatric respiratory co-infection and immunologic response: peds recon study protocol
Jones, M. U., Parsons, E. L., Kobi, P. A. K., Helfrich, A. M., King, D., Saunders, D. L. & Malloy, A. M. W., 2025, (Accepted/In press) In: Pediatric Research.Research output: Contribution to journal › Article › peer-review
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Precision Symptom Phenotyping Identifies Early Clinical and Proteomic Predictors of Distinct COVID-19 Sequelae
Epsi, N. J., Chenoweth, J. G., Blair, P. W., Lindholm, D. A., Ganesan, A., Lalani, T., Smith, A., Mody, R. M., Jones, M., Colombo, R. E., Colombo, C. J., Schofield, C., Ewers, E. C., Larson, D. T., Berjohn, C. M., Maves, R. C., Fries, A. C., Chang, D., Wyatt, A., Scher, A. I., & 16 others, 15 Jul 2025, In: Journal of Infectious Diseases. 232, 1, p. 39-49 11 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations
Press/Media
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New Findings from Uniformed Services University of the Health Sciences in the Area of COVID-19 Reported (Pediatric respiratory co-infection and immunologic response: peds recon study protocol)
David Saunders, Milissa Jones, Alison Helfrich & Allison Malloy
6/11/25
1 item of Media coverage
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New COVID-19 Study Findings Reported from Uniformed Services University of the Health Sciences (Pre-Vaccination Immune Profiles and Responsiveness to Innate Stimuli Predict Reactogenicity and Antibody Magnitude Following mRNA Vaccination)
Simon Pollett, Cara Olsen, Eric Laing, Edward Mitre & Allison Malloy
12/08/25
1 item of Media coverage
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Research from Uniformed Services University of the Health Sciences Reveals New Findings on COVID-19 (Precision symptom phenotyping identifies early clinical and proteomic predictors of distinct COVID-19 sequelae)
Timothy Burgess, Stephanie Richard, Robert J. O'Connell, Brian Agan, Simon Pollett, C. Byrne, David Lindholm, Katrin Mende, Mark Simons, Ann I. Scher, Anuradha Ganesan, Tahaniyat Lalani, David Tribble, David Saunders, Rhonda Colombo, Nusrat Epsi, Christopher Colombo, Christina Schofield, Jennifer A. Rusiecki, Catherine Berjohn, Milissa Jones, Allison Malloy & Jeffrey Livezey
11/07/24
1 item of Media coverage
Press/Media