Personal profile
Research interests
blast, severe musculoskeletal tissue loss and trauma, hemorrhagic shock, burn injury, and and neurotrauma
Biography
Dr. Rowe joined the Cellular Biology and Regenerative Medicine Program at the Uniformed Services University as a contractor at the Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) in 2019 under the mentorship of Dr. Thomas Davis. Dr. Rowe has an interdisciplinary background and training with over 8 years of experience in biological sciences, molecular biology, and neurosciences, with specific training in acute toxicology, neuroendocrinology, traumatic brain injury, blood-brain barrier disruption, cognition, neuroinflammation, and neuro-musculoskeletal injuries. Her current research interest involves the traumatic injury state, specifically neuromuscular extremity trauma and the neurobiological and physiological consequences underlying neuro-related disease conditions/pathologies (trauma-induced brain injury). She is also interested in sex-differences in disease states and the underlying molecular mechanisms of inflammatory pathways that regulate disease onset and progression. Dr. Rowe is involved in several projects related to the underlying neuro-immunological changes following military-relevant polytraumatic injury in many different model systems that give rise to disease pathologies. Dr. Rowe oversees all of the ongoing studies in the laboratory related to animal model development and surgeries, downstream proteomic/molecular assays, histological analyses, serves as the laboratory manager and mentors research assistants and student interns, and conducts data analyses using bioinformatics approach. Dr. Rowe is actively driving research characterizing region-specific transcriptomic level changes in the post-traumatic injury state of several rodent models of extremity polytrauma.
Dr. Rowe embarked on her scientific career at the Zebrafish Ecotoxicology, Neuropharmacology, and Vision Laboratory led by Dr. Victoria Connaughton at American University (AU). For her dissertation work, Dr. Rowe explored long-term complications of prolonged hyperglycemia using a zebrafish model. Dr. Rowe received several internal funding grants as well as an external research grant through Sigma XI, Scientific Research Society for her work. During her time at AU, she was the recipient of several awards for both academic/research performance and leadership. Dr. Rowe also worked in a neuroendocrinology lab under the direction of Dr. Colin Saldana where she conducted a biochemical aromatase activity assay as a direct measure of aromatase changes in the brain following peripheral injection of lipopolysaccharide in the zebra finch model of secondary injury. Dr. Rowe received her PhD in Behavior, Cognition, and Neuroscience from American University in 2019.
Education/Academic qualification
PhD, PhD, American University
… → 2019
Master, Master of Science, American University
… → 2016
Bachelor, Bachelor of Science, Rochester Institute of Technology
… → 2014
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Collaborations and top research areas from the last five years
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Mitigation of Acute Kidney Injury by Canagliflozin is associated with Increased Apoptosis and Mitochondrial Fission in a Porcine Model of Hemorrhagic Shock
Killingsworth, Z., Mares, J. A., Hutzler, J. D., Rowe, C., Stewart, I., Walker, P. & Burmeister, D., 7 Mar 2025.Research output: Contribution to conference › Abstract › peer-review
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Cutaneous burn injury represents a major risk factor for the development of traumatic ectopic bone formation following blast-related extremity injury
Rowe, C. J., Nwaolu, U., Salinas, D., Lansford, J. L., McCarthy, C. F., Anderson, J. A., Valerio, M. S., Potter, B. K., Spreadborough, P. J. & Davis, T. A., Apr 2024, In: Bone. 181, p. 117029 117029.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Systemic inflammation following traumatic injury and its impact on neuroinflammatory gene expression in the rodent brain
Rowe, C. J., Nwaolu, U., Martin, L., Huang, B. J., Mang, J., Salinas, D., Schlaff, C. D., Ghenbot, S., Lansford, J. L., Potter, B. K., Schobel, S. A., Gann, E. R. & Davis, T. A., 28 Aug 2024, In: Journal of Neuroinflammation. 21, 1, p. 211 211.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Identification of subacute behavioral deficits following repetitive moderate levels of blast overpressure
Salinas, D., Nwaolu, U., Tucker, L., Davis, T. & Rowe, C., 5 Dec 2023.Research output: Contribution to conference › Poster
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Identification of subacute behavioral deficits following repetitive moderate levels of blast overpressure
Salinas, D., Nwaolu, U., Tucker, L., Davis, T. & Rowe, C., 5 Dec 2023.Research output: Contribution to conference › Abstract
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A python-based code for high-throughput RT-qPCR analysis: application for surveying neuroinflammatory gene expression changes across regional brain samples following various forms of trauma
Cassie Rowe (Speaker)
7 Feb 2024Activity: Talk or presentation › Invited talk
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The impact of trauma etiology on cerebral neuroinflammation.
Cassie Rowe (Speaker)
19 Oct 2023Activity: Talk or presentation › Oral presentation
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Military Health Research Symposium 2023 (Event)
Cassie Rowe (Reviewer)
Mar 2023 → Apr 2023Activity: Publication peer-review and editorial work › Publication Peer-review
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Military Health System Research Symposium 2022 (Event)
Cassie Rowe (Reviewer)
Feb 2022 → Mar 2022Activity: Publication peer-review and editorial work › Publication Peer-review
Press/Media
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Reports Outline Blood Transfusion Findings from Uniformed Services University of the Health Sciences (Neutrophil Gelatinase-Associated Lipocalin: A Shared Early Biomarker of Remote Organ Dysfunction in Blast-Induced Extremity Trauma)
Philip Spreadborough, Cassie Rowe & Thomas Davis
12/09/25
1 item of Media coverage
Press/Media
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Report Summarizes Biomarkers Study Findings from Uniformed Services University of the Health Sciences (Systemic inflammation following traumatic injury and its impact on neuroinflammatory gene expression in the rodent brain)
Eric Gann, Thomas Davis, Benjamin K Potter, Seth Schobel-McHugh & Cassie Rowe
12/09/24
1 item of Media coverage
Press/Media
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Uniformed Services University of the Health Sciences Researchers Add New Data to Research in Heterotopic Ossification (Inhibition of focal adhesion kinase 2 results in a macrophage polarization shift to M2 which attenuates local and systemic ...)
Thomas Davis, Benjamin K Potter & Cassie Rowe
15/12/23
1 item of Media coverage
Press/Media
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Uniformed Services University of the Health Sciences Reports Findings in Military and Defense (Systemic inflammation induced from remote extremity trauma is a critical driver of secondary brain injury)
Thomas Davis, Benjamin K Potter, Seth Schobel-McHugh, Eric Gann & Cassie Rowe
31/07/23
1 item of Media coverage
Press/Media
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Studies Conducted at Uniformed Services University of the Health Sciences on Ischemia Recently Reported (Tourniquet-induced Ischemia Creates Increased Risk of Organ Dysfunction and Mortality Following Delayed Limb Amputation)
Thomas Davis, Benjamin K Potter, Sarah Walsh, Cassie Rowe & Philip Spreadborough
11/07/23
1 item of Media coverage
Press/Media