Personal profile
Research interests
The mechanisms that activate and repress intracellular protein breakdown and pharmacologically-modulating protein degradation to treat disease
Education/Academic qualification
Neuroscience, PhD, University at Buffalo
Award Date: 1 Feb 2017
Keywords
- QP Physiology
- Protein degradation
- Proteasome
- Ubiquitin
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Dive into the research topics where Jordan Verplank is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy
Verplank, J. J. S., Gawron, J. M., Silvestri, N. J., Wrabetz, L. & Feltri, M. L., Apr 2024, In: Life Science Alliance. 7, 4, e202302349.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Pharmacologically increasing cGMP improves proteostasis and reduces neuropathy in mouse models of CMT1
Moore, S. M., Gawron, J., Stevens, M., Marziali, L. N., Buys, E. S., Milne, G. T., Feltri, M. L. & VerPlank, J. J. S., Dec 2024, In: Cellular and Molecular Life Sciences. 81, 1, 434.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Raising cGMP restores proteasome function and myelination in mice with a proteotoxic neuropathy
Verplank, J. J. S., Gawron, J., Silvestri, N. J., Feltri, M. L., Wrabetz, L. & Goldberg, A. L., 1 Jan 2022, In: Brain. 145, 1, p. 168-178 11 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
CGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases
VerPlank, J. J. S., Tyrkalska, S. D., Tyrkalska, S. D., Tyrkalska, S. D., Fleming, A., Fleming, A., Fleming, A., Rubinsztein, D. C. & Goldberg, A. L., 23 Jun 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14220-14230 11 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Scopus citations -
26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation
VerPlank, J. J. S., Lokireddy, S., Zhao, J. & Goldberg, A. L., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4228-4237 10 p.Research output: Contribution to journal › Article › peer-review
Open Access101 Scopus citations