Marzena Pazgier

2024

Conformational dynamics of the HIV-1 envelope glycoprotein from CRF01_AE is associated with susceptibility to antibody-dependent cellular cytotoxicity

Díaz-Salinas, M. A., Chatterjee, D., Nayrac, M., Medjahed, H., Prévost, J., Pazgier, M., Finzi, A. & Munro, J. B., 22 Aug 2024, In: bioRxiv : the preprint server for biology.

Research output: Contribution to journal › Article › peer-review

Genetics of Exertional Heat Illness: Revealing New Associations and Expanding Heterogeneity

Sambuughin, N., Mungunsukh, O., Klein, M. G., Ren, M., Bedocs, P., Kazman, J. B., Cofer, K., Friel, L. P., McNally, B., Kwon, K., Haigney, M. C., Leggit, J. C., Pazgier, M., Deuster, P. A. & O’Connor, F. G., Oct 2024, In: International Journal of Molecular Sciences. 25, 20, 11269.

Research output: Contribution to journal › Article › peer-review

Open Access

Immune response profiles from humans experimentally exposed to Phlebotomus duboscqi bites

de Araujo, F. F., Abdeladhim, M., Teixeira, C., Hummer, K., Wilkerson, M. D., Ressner, R., Lakhal-Naouar, I., Ellis, M. W., Meneses, C., Nurmukhambetova, S., Gomes, R., Tolbert, W. D., Turiansky, G. W., Pazgier, M., Oliveira, F., Valenzuela, J. G., Kamhawi, S. & Aronson, N., 2024, In: Frontiers in Immunology. 15, 1335307.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy–Treated Individuals With Undetectable Viremia

on behalf of the Canadian HIV and Aging Cohort Study, 15 Mar 2024, In: Journal of Infectious Diseases. 229, 3, p. 763-774 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Structure and inhibition of SARS-CoV-2 spike refolding in membranes

Grunst, M. W., Qin, Z., Dodero-Rojas, E., Ding, S., Prévost, J., Chen, Y., Hu, Y., Pazgier, M., Wu, S., Xie, X., Finzi, A., Onuchic, J. N., Whitford, P. C., Mothes, W. & Li, W., 16 Aug 2024, In: Science. 385, 6710, p. 757-765 9 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Temperature-dependent Spike-ACE2 interaction of Omicron subvariants is associated with viral transmission

Benlarbi, M., Ding, S., Bélanger, É., Tauzin, A., Poujol, R., Medjahed, H., Ferri, O. E., Bo, Y., Bourassa, C., Hussin, J., Fafard, J., Pazgier, M., Levade, I., Abrams, C., Côté, M. & Finzi, A., 1 Aug 2024, In: mBio. 15, 8

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

Guillaume-Beaudoin-Buissières, 27 Aug 2024, In: bioRxiv : the preprint server for biology.

Research output: Contribution to journal › Article › peer-review

The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity

Marchitto, L., Richard, J., Prévost, J., Tauzin, A., Yang, D., Chiu, T., Chen, H-C., Díaz-Salinas, M. A., Nayrac, M., Benlarbi, M., Beaudoin-Bussières, G., Anand, S. P., Dionne, K., Bélanger, É., Chatterjee, D., Medjahed, H., Bourassa, C., Tolbert, W. D., Hahn, B. H., Munro, J. B., & 3 othersPazgier, M., Smith, A. B. & Finzi, A., 7 Jun 2024, In: bioRxiv : the preprint server for biology.

Research output: Contribution to journal › Article › peer-review

Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics

Tauzin, A., Marchitto, L., Bélanger, É., Benlarbi, M., Beaudoin-Bussières, G., Prévost, J., Yang, D., Chiu, T-J., Chen, H-C., Bourassa, C., Medjahed, H., Korzeniowski, M. K., Gottumukkala, S., Tolbert, W. D., Richard, J., Smith, A. B., Pazgier, M. & Finzi, A., 4 Jun 2024, In: medrxiv.

Research output: Contribution to journal › Article › peer-review

Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics

Tauzin, A., Marchitto, L., Bélanger, É., Benlarbi, M., Beaudoin-Bussières, G., Prévost, J., Yang, D., Chiu, T-J., Chen, H-C., Bourassa, C., Medjahed, H., Korzeniowski, M. K., Gottumukkala, S., Tolbert, W. D., Richard, J., Smith, A. B., Pazgier, M. & Finzi, A., 4 Sep 2024, (E-pub ahead of print) In: Journal of Virology. p. e0096024

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2023

Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates

Matsumoto, K., Kuwata, T., Tolbert, W. D., Richard, J., Ding, S., Prévost, J., Takahama, S., Judicate, G. P., Ueno, T., Nakata, H., Kobayakawa, T., Tsuji, K., Tamamura, H., Smith, A. B., Pazgier, M., Finzi, A. & Matsushita, S., Jan 2023, In: Journal of Virology. 97, 1

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Defining genetic diversity of rhesus macaque Fcγ receptors with long-read RNA sequencing

Conley, H. E., He, M. M., Easterhoff, D., Kirshner, H. F., Cocklin, S. L., Meyer, J., Hoxie, T., Berry, M., Bradley, T., Tolbert, W. D., Pazgier, M., Tomaras, G. D., Schmitz, J. E., Moody, M. A., Wiehe, K. & Pollara, J., 2023, In: Frontiers in Immunology. 14, 1306292.

Research output: Contribution to journal › Article › peer-review

Open Access

Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD

Chen, Y., Prévost, J., Ullah, I., Romero, H., Lisi, V., Tolbert, W. D., Grover, J. R., Ding, S., Gong, S. Y., Beaudoin-Bussières, G., Gasser, R., Benlarbi, M., Vézina, D., Anand, S. P., Chatterjee, D., Goyette, G., Grunst, M. W., Yang, Z., Bo, Y., Zhou, F., & 21 othersBéland, K., Bai, X., Zeher, A. R., Huang, R. K., Nguyen, D. N., Sherburn, R., Wu, D., Piszczek, G., Paré, B., Matthies, D., Xia, D., Richard, J., Kumar, P., Mothes, W., Côté, M., Uchil, P. D., Lavallée, V-P., Smith, M. A., Pazgier, M., Haddad, E. & Finzi, A., 20 Jan 2023, In: iScience. 26, 1, p. 105783

Research output: Contribution to journal › Article › peer-review

Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD

Chen, Y., Prévost, J., Ullah, I., Romero, H., Lisi, V., Tolbert, W. D., Grover, J. R., Ding, S., Gong, S. Y., Beaudoin-Bussières, G., Gasser, R., Benlarbi, M., Vézina, D., Anand, S. P., Chatterjee, D., Goyette, G., Grunst, M. W., Yang, Z., Bo, Y., Zhou, F., & 21 othersBéland, K., Bai, X., Zeher, A. R., Huang, R. K., Nguyen, D. N., Sherburn, R., Wu, D., Piszczek, G., Paré, B., Matthies, D., Xia, D., Richard, J., Kumar, P., Mothes, W., Côté, M., Uchil, P. D., Lavallée, V. P., Smith, M. A., Pazgier, M., Haddad, E. & Finzi, A., 20 Jan 2023, In: iScience. 26, 1, 105783.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Mouse a-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt

Wang, Q., Yang, Y., Luo, G., Zhou, Y., Tolbert, W. D., Pazgier, M., Liao, C. & Lu, W., Jan 2023, In: Infection and Immunity. 91, 1

Research output: Contribution to journal › Article › peer-review

Open Access

Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC

Ding, S., Tolbert, W. D., Zhu, H., Lee, D., Marchitto, L., Higgins, T., Zhao, X., Nguyen, D., Sherburn, R., Richard, J., Gendron-Lepage, G., Medjahed, H., Mohammadi, M., Abrams, C., Pazgier, M., Smith, A. B. & Finzi, A., May 2023, In: Viruses. 15, 5, 1185.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir

Prévost, J., Chen, Y., Zhou, F., Tolbert, W. D., Gasser, R., Medjahed, H., Nayrac, M., Nguyen, D. N., Gottumukkala, S., Hessell, A. J., Rao, V. B., Pozharski, E., Huang, R. K., Matthies, D., Finzi, A. & Pazgier, M., Dec 2023, In: Nature Communications. 14, 1, 6710.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120

Richard, J., Prévost, J., Bourassa, C., Brassard, N., Boutin, M., Benlarbi, M., Goyette, G., Medjahed, H., Gendron-Lepage, G., Gaudette, F., Chen, H. C., Tolbert, W. D., Smith, A. B., Pazgier, M., Dubé, M., Clark, A., Mothes, W., Kaufmann, D. E. & Finzi, A., 18 May 2023, In: Cell Chemical Biology. 30, 5, p. 540-552.e6

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11

Tolbert, W. D., Chen, Y., Sun, L., Benlarbi, M., Ding, S., Manickam, R., Pangaro, E., Nguyen, D. N., Gottumukkala, S., Côté, M., Gonzalez, F. J., Finzi, A., Tehrani, Z. R., Sajadi, M. M. & Pazgier, M., 2023, In: Frontiers in Immunology. 14, 1178355.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2022

A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

Beaudoin-Bussières, G., Chen, Y., Ullah, I., Prévost, J., Tolbert, W. D., Symmes, K., Ding, S., Benlarbi, M., Gong, S. Y., Tauzin, A., Gasser, R., Chatterjee, D., Vézina, D., Goyette, G., Richard, J., Zhou, F., Stamatatos, L., McGuire, A. T., Charest, H., Roger, M., & 6 othersPozharski, E., Kumar, P., Mothes, W., Uchil, P. D., Pazgier, M. & Finzi, A., 15 Feb 2022, In: Cell Reports. 38, 7, 110368.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis

Flynn, A. F., Taylor, R. T., Pazgier, M. E., Bennuru, S., Lindrose, A. R., Sterling, S. L., Morris, C. P., Gleeson, B. I., Maugel, T. K., Nutman, T. B. & Mitre, E., Jun 2022, In: mBio. 13, 3

Research output: Contribution to journal › Article › peer-review

Open Access

Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates

Matsumoto, K., Kuwata, T., Tolbert, W. D., Richard, J., Ding, S., Prévost, J., Takahama, S., Judicate, G. P., Ueno, T., Nakata, H., Kobayakawa, T., Tsuji, K., Tamamura, H., Smith, A. B., Pazgier, M., Finzi, A. & Matsushita, S., 13 Dec 2022, (E-pub ahead of print) In: Journal of Virology. p. e0163822

Research output: Contribution to journal › Article › peer-review

Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques

Tolbert, W. D., Gohain, N., Kremer, P. G., Hederman, A. P., Nguyen, D. N., Van, V., Sherburn, R., Lewis, G. K., Finzi, A., Pollara, J., Ackerman, M. E., Barb, A. W. & Pazgier, M., 5 Sep 2022, In: Frontiers in Immunology. 13, 960411.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

Chen, Y., Sun, L., Ullah, I., Beaudoin-Bussières, G., Anand, S. P., Hederman, A. P., Tolbert, W. D., Sherburn, R., Nguyen, D. N., Marchitto, L., Ding, S., Wu, D., Luo, Y., Gottumukkala, S., Moran, S., Kumar, P., Piszczek, G., Mothes, W., Ackerman, M. E., Finzi, A., & 3 othersUchil, P. D., Gonzalez, F. J. & Pazgier, M., Jul 2022, In: Science Advances. 8, 28, eabn4188.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

Prévost, J., Anand, S. P., Rajashekar, J. K., Zhu, L., Richard, J., Goyette, G., Medjahed, H., Gendron-Lepage, G., Chen, H. C., Chen, Y., Horwitz, J. A., Grunst, M. W., Zolla-Pazner, S., Haynes, B. F., Burton, D. R., Flavell, R. A., Kirchhoff, F., Hahn, B. H., Smith, A. B., Pazgier, M., & 3 othersNussenzweig, M. C., Kumar, P. & Finzi, A., 8 Nov 2022, In: Cell Reports. 41, 6, 111624.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19

Esparza, T. J., Chen, Y., Martin, N. P., Bielefeldt-Ohmann, H., Bowen, R. A., Tolbert, W. D., Pazgier, M. & Brody, D. L., 2022, In: mAbs. 14, 1, 2047144.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

Li, W., Chen, Y., Prévost, J., Ullah, I., Lu, M., Gong, S. Y., Tauzin, A., Gasser, R., Vézina, D., Anand, S. P., Goyette, G., Chaterjee, D., Ding, S., Tolbert, W. D., Grunst, M. W., Bo, Y., Zhang, S., Richard, J., Zhou, F., Huang, R. K., & 10 othersEsser, L., Zeher, A., Côté, M., Kumar, P., Sodroski, J., Xia, D., Uchil, P. D., Pazgier, M., Finzi, A. & Mothes, W., 11 Jan 2022, In: Cell Reports. 38, 2, 110210.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s

Tolbert, W. D., Nguyen, D. N., Tuyishime, M., Crowley, A. R., Chen, Y., Jha, S., Goodman, D., Bekker, V., Mudrak, S. V., DeVico, A. L., Lewis, G. K., Theis, J. F., Pinter, A., Moody, M. A., Easterhoff, D., Wiehe, K., Pollara, J., Saunders, K. O., Tomaras, G. D., Ackerman, M., & 2 othersFerrari, G. & Pazgier, M., 6 Jan 2022, In: Frontiers in Immunology. 12, 787603.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Temperature Influences the Interaction between SARS-CoV-2 Spike from Omicron Subvariants and Human ACE2

Gong, S. Y., Ding, S., Benlarbi, M., Chen, Y., Vézina, D., Marchitto, L., Beaudoin-Bussières, G., Goyette, G., Bourassa, C., Bo, Y., Medjahed, H., Levade, I., Pazgier, M., Côté, M., Richard, J., Prévost, J. & Finzi, A., Oct 2022, In: Viruses. 14, 10, 2178.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

VE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry

Ding, S., Ullah, I., Gong, S. Y., Grover, J. R., Mohammadi, M., Chen, Y., Vézina, D., Beaudoin-Bussières, G., Verma, V. T., Goyette, G., Gaudette, F., Richard, J., Yang, D., Smith, A. B., Pazgier, M., Côté, M., Abrams, C., Kumar, P., Mothes, W., Uchil, P. D., & 2 othersFinzi, A. & Baron, C., 15 Jul 2022, In: iScience. 25, 7, 104528.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2021

Across Functional Boundaries: Making Nonneutralizing Antibodies to Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells

Richard, J., Nguyen, D. N., Tolbert, W. D., Gasser, R., Ding, S., Vézina, D., Yu Gong, S., Prévost, J., Gendron-Lepage, G., Medjahed, H., Gottumukkala, S., Finzi, A. & Pazgier, M., 1 Oct 2021, In: mBio. 12, 5, e01405-21.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression

Li, X., Gohain, N., Chen, S., Li, Y., Zhao, X., Li, B., Tolbert, W. D., He, W., Pazgier, M., Hu, H. & Lu, W., Sep 2021, In: Acta Pharmaceutica Sinica B. 11, 9, p. 2655-2669 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Enhanced ability of plant-derived PGT121 glycovariants to eliminate HIV-1-infected cells

Anand, S. P., Ding, S., Tolbert, W. D., Prévost, J., Richard, J., Gil, H. M., Gendron-Lepage, G., Cheung, W. F., Wang, H., Pastora, R., Saxena, H., Wakarchuk, W., Medjahed, H., Wines, B. D., Hogarth, M., Shaw, G. M., Martin, M. A., Burton, D. R., Hangartner, L., Evans, D. T., & 4 othersPazgier, M., Cossar, D., McLean, M. D. & Finzi, A., Sep 2021, In: Journal of Virology. 95, 18, e00796-21.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Erratum for Tolbert et al., “recognition patterns of the c1/c2 epitopes involved in fc-mediated response in hiv-1 natural infection and the rv114 vaccine trial”(mBio (2020) 11, 3, e00208-20.)

Tolbert, W. D., Van, V., Sherburn, R., Tuyishime, M., Yan, F., Nguyen, D. N., Stanfield-Oakley, S., Easterhoff, D., Bonsignori, M., Haynes, B. F., Moody, M. A., Ray, K., Ferrari, G., Lewis, G. K. & Pazgier, M., 2021, In: mBio. 12, 2, e00474-21.

Research output: Contribution to journal › Comment/debate

Open Access

Hiv-1 envelope glycoprotein cell surface localization is associated with antibody-induced internalization

Anand, S. P., Prévost, J., Descôteaux-Dinelle, J., Richard, J., Nguyen, D. N., Medjahed, H., Chen, H. C., Smith, A. B., Pazgier, M. & Finzi, A., Oct 2021, In: Viruses. 13, 10, 1953.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2

Prévost, J., Richard, J., asser, R., Ding, S., Fage, C., Anand, S. P., Adam, D., Vergara, N. G., auzin, A., Benlarbi, M., Gong, S. Y., oyette, G., Privé, A., Moreira, S., Charest, H., Roger, M., Mothes, W., Pazgier, M., Brochiero, E., Boivin, G., & 3 othersAbrams, C. F., Schön, A. & Finzi, A., 1 Oct 2021, In: Journal of Biological Chemistry. 297, 4, 101151.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Incorporating the cluster a and v1v2 targets into a minimal structural unit of the hiv-1 envelope to elicit a cross-clade response with potent fc-effector functions

Sherburn, R., Tolbert, W. D., Gottumukkala, S., Hederman, A. P., Beaudoin-Bussières, G., Stanfield-Oakley, S., Tuyishime, M., Ferrari, G., Finzi, A., Ackerman, M. E. & Pazgier, M., Sep 2021, In: Vaccines. 9, 9, 975.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

Ullah, I., Prévost, J., Ladinsky, M. S., Stone, H., Lu, M., Anand, S. P., Beaudoin-Bussières, G., Symmes, K., Benlarbi, M., Ding, S., Gasser, R., Fink, C., Chen, Y., Tauzin, A., Goyette, G., Bourassa, C., Medjahed, H., Mack, M., Chung, K., Wilen, C. B., & 13 othersDekaban, G. A., Dikeakos, J. D., Bruce, E. A., Kaufmann, D. E., Stamatatos, L., McGuire, A. T., Richard, J., Pazgier, M., Bjorkman, P. J., Mothes, W., Finzi, A., Kumar, P. & Uchil, P. D., 14 Sep 2021, In: Immunity. 54, 9, p. 2143-2158.e15

Research output: Contribution to journal › Article › peer-review

Open Access

136 Scopus citations

Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir

Rajashekar, J. K., Richard, J., Beloor, J., Prévost, J., Anand, S. P., Beaudoin-Bussières, G., Shan, L., Herndler-Brandstetter, D., Gendron-Lepage, G., Medjahed, H., Bourassa, C., Gaudette, F., Ullah, I., Symmes, K., Peric, A., Lindemuth, E., Bibollet-Ruche, F., Park, J., Chen, H. C., Kaufmann, D. E., & 7 othersHahn, B. H., Sodroski, J., Pazgier, M., Flavell, R. A., Smith, A. B., Finzi, A. & Kumar, P., 9 Jun 2021, In: Cell Host and Microbe. 29, 6, p. 904-916.e6

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Near-pan-neutralizing, plasma deconvoluted antibody N49P6 mimics host receptor CD4 in its quaternary interactions with the HIV-1 envelope trimer

Tolbert, W. D., Nguyen, D. N., Tehrani, Z. R., Sajadi, M. M. & Pazgier, M., Aug 2021, In: mBio. 12, 4, e01274-21.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological and pathological disease in a Syrian hamster model of COVID-19

Esparza, T. J., Chen, Y., Martin, N. P., Bielefeldt-Ohmann, H., Bowen, R. A., Tolbert, W. D., Pazgier, M. & Brody, D. L., 12 Nov 2021, In: bioRxiv : the preprint server for biology.

Research output: Contribution to journal › Article › peer-review

Stabilizing the HIV-1 envelope glycoprotein state 2A conformation

Vézina, D., Gong, S. Y., Tolbert, W. D., Ding, S., Nguyen, D., Richard, J., Gendron-Lepage, G., Melillo, B., Smith, A. B., Pazgier, M. & Finzi, A., Mar 2021, In: Journal of Virology. 95, 5, e01620-20.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2020

Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding

Orlandi, C., Deredge, D., Ray, K., Gohain, N., Tolbert, W., DeVico, A. L., Wintrode, P., Pazgier, M. & Lewis, G. K., 5 May 2020, In: Structure. 28, 5, p. 516-527.e5

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Boosting with AIDSvax B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity breadth and potency

Easterhoff, D., Pollara, J., Luo, K., Tolbert, W. D., Young, B., Mielke, D., Jha, S., O’Connell, R. J., Vasan, S., Kim, J., Michael, N. L., Excler, J. L., Robb, M. L., Rerks-Ngarm, S., Kaewkungwal, J., Pitisuttithum, P., Nitayaphan, S., Sinangil, F., Tartaglia, J., Phogat, S., & 10 othersKepler, T. B., Alam, S. M., Wiehe, K., Saunders, K. O., Montefiori, D. C., Tomaras, G. D., Moody, M. A., Pazgier, M., Haynes, B. F. & Ferrari, G., 1 Feb 2020, In: Journal of Virology. 94, 4, e01120-19.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site

Tolbert, W. D., Sherburn, R., Gohain, N., Ding, S., Flinko, R., Orlandi, C., Ray, K., Finzi, A., Lewis, G. K. & Pazgier, M., 21 Jul 2020, In: BMC Biology. 18, 1, 91.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Effects of GP120 inner domain (ID2) immunogen doses on elicitation of anti-HIV-1 functional FC-effector response to C1/C2 (cluster a) epitopes in mice

Sherburn, R., Tolbert, W. D., Gottumukkala, S., Beaudoin-Bussières, G., Finzi, A. & Pazgier, M., Oct 2020, In: Microorganisms. 8, 10, p. 1-17 17 p., 1490.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Elicitation of cluster a and co-receptor binding site antibodies are required to eliminate HIV-1 infected cells

Beaudoin-Bussières, G., Prévost, J., Gendron-Lepage, G., Melillo, B., Chen, J., Smith, A. B., Pazgier, M. & Finzi, A., May 2020, In: Microorganisms. 8, 5, 710.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Interaction of human ACE2 to membrane-bound SARS-CoV-1 and SARS-CoV-2 S glycoproteins

Anand, S. P., Chen, Y., Prévost, J., Gasser, R., Beaudoin-Bussières, G., Abrams, C. F., Pazgier, M. & Finzi, A., Oct 2020, In: Viruses. 12, 10, 1104.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity

Grenier, M. C., Ding, S., Vézina, D., Chapleau, J. P., Tolbert, W. D., Sherburn, R., Schön, A., Somisetti, S., Abrams, C. F., Pazgier, M., Finzi, A. & Smith, A. B., 12 Mar 2020, In: ACS Medicinal Chemistry Letters. 11, 3, p. 371-378 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Recognition patterns of the c1/c2 epitopes involved in fc-mediated response in hiv-1 natural infection and the rv114 vaccine trial

Tolbert, W. D., Van, V., Sherburn, R., Tuyishime, M., Yan, F., Nguyen, D. N., Stanfield-Oakley, S., Easterhoff, D., Bonsignori, M., Haynes, B. F., Moody, M. A., Ray, K., Ferrari, G., Lewis, G. K. & Pazgier, M., 1 May 2020, In: mBio. 11, 3, p. 1-22 22 p., e00208-20.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Marzena Pazgier

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