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Personal profile


Dr Michael Klein is a biomedical researcher interested in the elucidation
of cellular metabolic processes, especially related to regulation by
electrical signaling.  He worked on the control of calcium regulation
and contractility in skeletal muscle at the University of Maryland, Baltimore,
followed by his current appointment at the USUHS in Bethesda, MD, investigating
mechanisms of drug and heart-failure induced cardiac rhythm instability.


Research interests

I am interested in cellular physiology related to signaling mechanisms in heart cells.

Our ongoing research interests involve investigation of cardiac electrophysiology in three experimental model systems, i) isolated cardiac myocytes from large animals (swine), ii) human heart cells derived from induced pluripotent stem cells (hiPSC CMs) and iii) heterologous expression of ion channel proteins associated with electrical excitation in the heart. Three ongoing research projects involve i) characterization of cardiac toxicity of opioids, including methadone, loperamide and mitragynine, ii) regulation of Kir2 activity which is responsible for the inward rectifier current (IK1) and iii) medium-throughput electrical and optical measurements of heart cell functional activity.

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