Developing an algorithm for Molecular Tailored Therapy

  • Brody, Jonathan R. J.R. (PI)
  • Petricoin, Emanuel F. E.F. (CoPI)
  • Albanese, Christopher C. (CoPI)
  • Madhavan, Subha S. (CoPI)
  • Pishvaian, Michael J. M.J. (CoPI)

Project Details


The team previously conducted a pilot trial that demonstrated the feasibility of delivering Molecularly Tailored Therapy (MTT) for metastatic pancreatic cancer patients. In this project, they are evaluating the benefits of MTT versus physician-selected standard of care for patients with metastatic disease. In addition, they are leveraging the findings from the clinical trial to interrogate and define a set of network models representing major relevant changes in pancreatic cancer cells that associate significantly with response or resistance to standard therapies. This work is expected to culminate in a version 2.0 molecular algorithm for the next, larger clinical trial. The team is also defining novel chemoresistance mechanisms and identifying targets to overcome such resistance in pancreatic cancer cells.
Effective start/end date1/01/15 → …


  • Pancreatic Cancer Action Network: $1,000,000.00
  • American Association for Cancer Research


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.