Development of Combat-Applicable Lower Extremity Trauma Models Incorporating the Effects of Ischemia Reperfusion Injury Relevant to Prolonged Field Care

Background: Prolonged field care (PFC) was designated in a Capabilities Needs Analysis as the number one gap across the U.S. Army. Uncontrolled hemorrhage remains the leading cause of preventable death following trauma, accounting for 30% of deaths. The forward deployment of tourniquets to all personnel has helped reduce death from catastrophic hemorrhage in extremity trauma. During Iraq, >91% of cases had an application time