Extracellular Matrix (ECM) Scaffolds for Beta Cell Regeneration

We have developed biologic scaffolds derived from the extracellular matrix (ECM) from a variety of tissues and organs. These various ECMs appear to promote the selective differentiation of cells by creating a microenvironment that sends instructive signals. For example, pancreatic ECM has the potential to promote the differentiation of pancreatic cell types such as insulin secreting islet cells. All preliminary evidence and proposed studies will determine whether or not this represents a feasible approach to the treatment of Type I Diabetes in human patients.

We will isolate ECM biologic scaffolds from numerous organs including the liver and pancreas. We will determine the ability to promote the differentiation of cells toward insulin secreting cells both in vitro (cell culture) and in vivo. Importantly, we will serve as a resource of ECM scaffolds for other investigators funded by JDRF in their attempts to generate islet cells for the treatment of Type I Diabetes.