Project Details
Description
This project is to examine the mechanisms of Ang regulation by HGF. Ang is pro-fibrotic and HGF is an antifibrotic factor. Primary lung cells will be used.
Layman's description
This study is to understand how to prevent scar formation in lung tissue. Lung fibrosis is a fatal condition with no cure except lung transplantation.
Key findings
We identified some molecular pathways that are activated by HGF to regulate Ang expression.
| Short title | HGF regulation of Angiotensinogen |
|---|---|
| Status | Finished |
| Effective start/end date | 1/06/03 → 31/05/05 |
Funding
- American Heart Association: $80,000.00
Keywords
- lung fibrosis, hepatocyte growth factor, angiotensinogen, gene expression, cell signaling