Project Details
Description
This project examined the regulation of TGFb1, angiotensinogen and angiotensin converting enzyme in primary lung cells and in vivo by the chemotherapeutic agent bleomycin and by ionizing radiation.
Layman's description
Lung fibrosis is a fatal disease in which the lung continues to accumulate scar tissue. This project was aimed at understanding how specific proteins are regulated to result in scar tissue formation in the lung.
Key findings
mechanisms of regulation of TGFb1, angiotensinogen and ACE
| Short title | Bleomycin regulation of TGF-b1 |
|---|---|
| Status | Finished |
| Effective start/end date | 1/02/01 → 1/10/03 |
Funding
- American Lung Association: $70,000.00
- NIH-NHLBI: $700,000.00
- Intramural Research Program: $12,500.00
Keywords
- bleomycin, chemotherapy, pulmonary fibrosis, TGF-b1, angiotensinogen
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