β-amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease

Zygmunt Galdzicki; Ryuichi Fukuyama; Kishena C. Wadhwani; Stanley I. Rapoport; Gerald Ehrenstein

doi:10.1016/0006-8993(94)90101-5

β-amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease

Zygmunt Galdzicki^*, Ryuichi Fukuyama, Kishena C. Wadhwani, Stanley I. Rapoport, Gerald Ehrenstein

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

When β-amyloid-(1-40) is added to PC12 cells, there is an increase in choline conductance that is proportional to the β-amyloid concentration. If a similar effect occurs in cholinergic brain cells of Alzheimer's disease patients, the intracellular choline concentration would be reduced, leading to a decrease in the production of acetylcholine. This could explain the reduced level of acetylcholine that has been found in post-mortem brain tissue of Alzheimer's disease patients.

Original language	English
Pages (from-to)	332-336
Number of pages	5
Journal	Brain Research
Volume	646
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)90101-5
State	Published - 23 May 1994

Keywords

Acetylcholine
Alzheimer's disease
Brain
Carrier
Choline
Leakage
Neuron
PC12 cell
β-Amyloid

Access to Document

10.1016/0006-8993(94)90101-5

Cite this

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title = "β-amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease",

abstract = "When β-amyloid-(1-40) is added to PC12 cells, there is an increase in choline conductance that is proportional to the β-amyloid concentration. If a similar effect occurs in cholinergic brain cells of Alzheimer's disease patients, the intracellular choline concentration would be reduced, leading to a decrease in the production of acetylcholine. This could explain the reduced level of acetylcholine that has been found in post-mortem brain tissue of Alzheimer's disease patients.",

keywords = "Acetylcholine, Alzheimer's disease, Brain, Carrier, Choline, Leakage, Neuron, PC12 cell, β-Amyloid",

author = "Zygmunt Galdzicki and Ryuichi Fukuyama and Wadhwani, {Kishena C.} and Rapoport, {Stanley I.} and Gerald Ehrenstein",

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AU - Fukuyama, Ryuichi

AU - Wadhwani, Kishena C.

AU - Rapoport, Stanley I.

AU - Ehrenstein, Gerald

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AB - When β-amyloid-(1-40) is added to PC12 cells, there is an increase in choline conductance that is proportional to the β-amyloid concentration. If a similar effect occurs in cholinergic brain cells of Alzheimer's disease patients, the intracellular choline concentration would be reduced, leading to a decrease in the production of acetylcholine. This could explain the reduced level of acetylcholine that has been found in post-mortem brain tissue of Alzheimer's disease patients.

KW - Acetylcholine

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KW - Brain

KW - Carrier

KW - Choline

KW - Leakage

KW - Neuron

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KW - β-Amyloid

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