5-HT(1A) receptor mRNA expressions differ in the embryonic spinal cord of male and female rats

Lei Zhang; Jeffery L. Barker; Gaoqing Xing; Osvaedo Giorgi; Wu Ma; Yoong H. Chang; Qian Hu; Nina Choi; David R. Rubinow

doi:10.1016/S0304-3940(97)00801-X

5-HT(1A) receptor mRNA expressions differ in the embryonic spinal cord of male and female rats

Lei Zhang^*, Jeffery L. Barker, Gaoqing Xing, Osvaedo Giorgi, Wu Ma, Yoong H. Chang, Qian Hu, Nina Choi, David R. Rubinow

^*Corresponding author for this work

Psychiatry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

During critical periods of development, the effects of testosterone (T) on promoting androgenization of the central nervous system (CNS) are reflected not only by behavior, morphology, and hormone secretion but also by gene expression. The mechanisms involved in sexual differentiation of the CNS, however, remain incompletely defined. The current set of experiments examined with in situ hybridization the dimorphism in 5-HT(1A) receptor mRNA expression in the embryonic rat spinal cord and the possible role of T in the dimorphism. We found sex-related differences in expression of 5-HT(1A) mRNA in the spinal cord, which were altered by a single injection of T. The results suggest that this gonadal steroid is responsible for the sexual dimorphism in 5-HT(1A) mRNA expression occurring during the critical period.

Original language	English
Pages (from-to)	41-44
Number of pages	4
Journal	Neuroscience Letters
Volume	237
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(97)00801-X
State	Published - 14 Nov 1997

Keywords

Dimorphism
Embryo
MRNA
Serotonin
Spinal cord
Testosterone

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10.1016/S0304-3940(97)00801-X

Cite this

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title = "5-HT(1A) receptor mRNA expressions differ in the embryonic spinal cord of male and female rats",

abstract = "During critical periods of development, the effects of testosterone (T) on promoting androgenization of the central nervous system (CNS) are reflected not only by behavior, morphology, and hormone secretion but also by gene expression. The mechanisms involved in sexual differentiation of the CNS, however, remain incompletely defined. The current set of experiments examined with in situ hybridization the dimorphism in 5-HT(1A) receptor mRNA expression in the embryonic rat spinal cord and the possible role of T in the dimorphism. We found sex-related differences in expression of 5-HT(1A) mRNA in the spinal cord, which were altered by a single injection of T. The results suggest that this gonadal steroid is responsible for the sexual dimorphism in 5-HT(1A) mRNA expression occurring during the critical period.",

keywords = "Dimorphism, Embryo, MRNA, Serotonin, Spinal cord, Testosterone",

author = "Lei Zhang and Barker, {Jeffery L.} and Gaoqing Xing and Osvaedo Giorgi and Wu Ma and Chang, {Yoong H.} and Qian Hu and Nina Choi and Rubinow, {David R.}",

year = "1997",

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doi = "10.1016/S0304-3940(97)00801-X",

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T1 - 5-HT(1A) receptor mRNA expressions differ in the embryonic spinal cord of male and female rats

AU - Zhang, Lei

AU - Barker, Jeffery L.

AU - Xing, Gaoqing

AU - Giorgi, Osvaedo

AU - Ma, Wu

AU - Chang, Yoong H.

AU - Hu, Qian

AU - Choi, Nina

AU - Rubinow, David R.

PY - 1997/11/14

Y1 - 1997/11/14

N2 - During critical periods of development, the effects of testosterone (T) on promoting androgenization of the central nervous system (CNS) are reflected not only by behavior, morphology, and hormone secretion but also by gene expression. The mechanisms involved in sexual differentiation of the CNS, however, remain incompletely defined. The current set of experiments examined with in situ hybridization the dimorphism in 5-HT(1A) receptor mRNA expression in the embryonic rat spinal cord and the possible role of T in the dimorphism. We found sex-related differences in expression of 5-HT(1A) mRNA in the spinal cord, which were altered by a single injection of T. The results suggest that this gonadal steroid is responsible for the sexual dimorphism in 5-HT(1A) mRNA expression occurring during the critical period.

AB - During critical periods of development, the effects of testosterone (T) on promoting androgenization of the central nervous system (CNS) are reflected not only by behavior, morphology, and hormone secretion but also by gene expression. The mechanisms involved in sexual differentiation of the CNS, however, remain incompletely defined. The current set of experiments examined with in situ hybridization the dimorphism in 5-HT(1A) receptor mRNA expression in the embryonic rat spinal cord and the possible role of T in the dimorphism. We found sex-related differences in expression of 5-HT(1A) mRNA in the spinal cord, which were altered by a single injection of T. The results suggest that this gonadal steroid is responsible for the sexual dimorphism in 5-HT(1A) mRNA expression occurring during the critical period.

KW - Dimorphism

KW - Embryo

KW - MRNA

KW - Serotonin

KW - Spinal cord

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