5-Hydroxytryptophan elevates serum melatonin

M. A.A. Namboodiri; D. Sugden; D. C. Klein; I. N. Mefford

doi:10.1126/science.6867734

5-Hydroxytryptophan elevates serum melatonin

M. A.A. Namboodiri^*, D. Sugden, D. C. Klein, I. N. Mefford

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Daytime administration of 5-hydroxytryptophan to sheep elevated serum melatonin more than sevenfold within 2 hours. This suggests that administration of 5-hydroxytryptophan could be used as the basis of a clinical test of pineal function and that melatonin might mediate some clinical effects of 5-hydroxytryptophan.

Original language	English
Pages (from-to)	659-661
Number of pages	3
Journal	Science
Volume	221
Issue number	4611
DOIs	https://doi.org/10.1126/science.6867734
State	Published - 1983

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10.1126/science.6867734

Cite this

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title = "5-Hydroxytryptophan elevates serum melatonin",

abstract = "Daytime administration of 5-hydroxytryptophan to sheep elevated serum melatonin more than sevenfold within 2 hours. This suggests that administration of 5-hydroxytryptophan could be used as the basis of a clinical test of pineal function and that melatonin might mediate some clinical effects of 5-hydroxytryptophan.",

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AB - Daytime administration of 5-hydroxytryptophan to sheep elevated serum melatonin more than sevenfold within 2 hours. This suggests that administration of 5-hydroxytryptophan could be used as the basis of a clinical test of pineal function and that melatonin might mediate some clinical effects of 5-hydroxytryptophan.

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