A brief episode of hypotension increases mortality in critically ill trauma patients

Mazen S. Zenati, Timothy R. Billiar, Ricard N. Townsend, Andrew B. Peitzman, Brian G. Harbrecht*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Objective Hypotension is associated with increased mortality, however previous studies have failed to account for the depth and duration of hypotension. We evaluated the effect of the duration of hypotension on outcome in injured patients. Methods Trauma patients admitted to the intensive care unit (ICU) from 1999 to 2000 were prosupectively evaluated. Patients transferred to a ward ≤ 48 hours after admission were excluded. The lowest systolic blood pressure and duration of all episodes of systolic blood pressure below 90 mm Hg were recorded along with the total ICU length of stay and discharge status. The Kruskal-Wallis test, Pearson 2and test for trend were used for analysis. Results Patients with hypotension during the first 24 hours of ICU care had an increased mortality rate. A brief (≤ 10 minutes) episode of hypotension was associated with increased mortality that increased with duration of hypotension (p = 0.0001). ICU length of stay also increased with duration of hypotension (p = 0.0001). Conclusion Brief episodes of hypotension are associated with an increased risk of death in patients requiring admission to the ICU after injury and a longer ICU recovery for those who survive.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number2
StatePublished - Aug 2002
Externally publishedYes


Dive into the research topics of 'A brief episode of hypotension increases mortality in critically ill trauma patients'. Together they form a unique fingerprint.

Cite this