A case of hereditary alpha tryptasemia and presumptive eosinophilic granulomatosis with polyangiitis

Sonia Iqbal; Joseph A. Baxter; Karla E. Adams

doi:10.1016/j.jacig.2025.100481

A case of hereditary alpha tryptasemia and presumptive eosinophilic granulomatosis with polyangiitis

Sonia Iqbal^*, Joseph A. Baxter, Karla E. Adams

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

This case is notable for the potential overlap of hereditary alpha tryptasemia and eosinophilic granulomatosis with polyangiitis. The successful use of mepolizumab, initially for eosinophilic granulomatosis with polyangiitis but potentially benefiting the patient's hereditary alpha tryptasemia, offers a novel approach to managing complex cases involving both rare disorders.

Original language	English
Article number	100481
Journal	Journal of Allergy and Clinical Immunology: Global
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.jacig.2025.100481
State	Published - Aug 2025

Keywords

elevated tryptase level
eosinophilic granulomatosis with polyangiitis
Hereditary alpha tryptasemia
hypereosinophilia
mepolizumab

Access to Document

10.1016/j.jacig.2025.100481

Cite this

@article{c8ccd5b8bbdb4fcc9d0b321684c7290d,

title = "A case of hereditary alpha tryptasemia and presumptive eosinophilic granulomatosis with polyangiitis",

abstract = "This case is notable for the potential overlap of hereditary alpha tryptasemia and eosinophilic granulomatosis with polyangiitis. The successful use of mepolizumab, initially for eosinophilic granulomatosis with polyangiitis but potentially benefiting the patient's hereditary alpha tryptasemia, offers a novel approach to managing complex cases involving both rare disorders.",

keywords = "elevated tryptase level, eosinophilic granulomatosis with polyangiitis, Hereditary alpha tryptasemia, hypereosinophilia, mepolizumab",

author = "Sonia Iqbal and Baxter, {Joseph A.} and Adams, {Karla E.}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s)",

year = "2025",

month = aug,

doi = "10.1016/j.jacig.2025.100481",

language = "English",

volume = "4",

journal = "Journal of Allergy and Clinical Immunology: Global",

issn = "2772-8293",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - A case of hereditary alpha tryptasemia and presumptive eosinophilic granulomatosis with polyangiitis

AU - Iqbal, Sonia

AU - Baxter, Joseph A.

AU - Adams, Karla E.

PY - 2025/8

Y1 - 2025/8

N2 - This case is notable for the potential overlap of hereditary alpha tryptasemia and eosinophilic granulomatosis with polyangiitis. The successful use of mepolizumab, initially for eosinophilic granulomatosis with polyangiitis but potentially benefiting the patient's hereditary alpha tryptasemia, offers a novel approach to managing complex cases involving both rare disorders.

AB - This case is notable for the potential overlap of hereditary alpha tryptasemia and eosinophilic granulomatosis with polyangiitis. The successful use of mepolizumab, initially for eosinophilic granulomatosis with polyangiitis but potentially benefiting the patient's hereditary alpha tryptasemia, offers a novel approach to managing complex cases involving both rare disorders.

KW - elevated tryptase level

KW - eosinophilic granulomatosis with polyangiitis

KW - Hereditary alpha tryptasemia

KW - hypereosinophilia

KW - mepolizumab

UR - http://www.scopus.com/inward/record.url?scp=105004294923&partnerID=8YFLogxK

U2 - 10.1016/j.jacig.2025.100481

DO - 10.1016/j.jacig.2025.100481

M3 - Article

AN - SCOPUS:105004294923

SN - 2772-8293

VL - 4

JO - Journal of Allergy and Clinical Immunology: Global

JF - Journal of Allergy and Clinical Immunology: Global

IS - 3

M1 - 100481

ER -