A Complicated Case of Aspirin-Exacerbated Respiratory Disease With Kounis Syndrome

Krista M Shaw; Brittanie I Neaves; Hayden A Springer; Christopher A Coop

doi:10.7759/cureus.45635

A Complicated Case of Aspirin-Exacerbated Respiratory Disease With Kounis Syndrome

Krista M Shaw, Brittanie I Neaves, Hayden A Springer, Christopher A Coop

Research output: Contribution to journal › Article › peer-review

Abstract

Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization and was then treated with high-dose aspirin. Unfortunately, he developed recurrent angina and myocardial infarction (MI). Numerous left heart catheterizations revealed vasospasms as the etiology of his MIs; however, therapy with increasing doses of vasodilators yielded no improvement in the patient's condition. Ultimately the patient's aspirin was discontinued and he had no recurrence of angina or MI.

Original language	English
Pages (from-to)	e45635
Journal	Cureus
Volume	15
Issue number	9
DOIs	https://doi.org/10.7759/cureus.45635
State	Published - Sep 2023
Externally published	Yes

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10.7759/cureus.45635

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title = "A Complicated Case of Aspirin-Exacerbated Respiratory Disease With Kounis Syndrome",

abstract = "Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization and was then treated with high-dose aspirin. Unfortunately, he developed recurrent angina and myocardial infarction (MI). Numerous left heart catheterizations revealed vasospasms as the etiology of his MIs; however, therapy with increasing doses of vasodilators yielded no improvement in the patient's condition. Ultimately the patient's aspirin was discontinued and he had no recurrence of angina or MI.",

author = "Shaw, {Krista M} and Neaves, {Brittanie I} and Springer, {Hayden A} and Coop, {Christopher A}",

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AU - Neaves, Brittanie I

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AU - Coop, Christopher A

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N2 - Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization and was then treated with high-dose aspirin. Unfortunately, he developed recurrent angina and myocardial infarction (MI). Numerous left heart catheterizations revealed vasospasms as the etiology of his MIs; however, therapy with increasing doses of vasodilators yielded no improvement in the patient's condition. Ultimately the patient's aspirin was discontinued and he had no recurrence of angina or MI.

AB - Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization and was then treated with high-dose aspirin. Unfortunately, he developed recurrent angina and myocardial infarction (MI). Numerous left heart catheterizations revealed vasospasms as the etiology of his MIs; however, therapy with increasing doses of vasodilators yielded no improvement in the patient's condition. Ultimately the patient's aspirin was discontinued and he had no recurrence of angina or MI.

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VL - 15

SP - e45635

JO - Cureus

JF - Cureus

IS - 9

ER -

A Complicated Case of Aspirin-Exacerbated Respiratory Disease With Kounis Syndrome

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