A critical appraisal of "chronic lyme disease"

Henry M. Feder; Barbara J.B. Johnson; Susan O'Connell; Eugene D. Shapiro; Allen C. Steere; Gary P. Wormser; W. A. Agger; H. Artsob; P. Auwaerter; J. S. Dumler; J. S. Bakken; L. K. Bockenstedt; J. Green; R. J. Dattwyler; J. Munoz; R. B. Nadelman; I. Schwartz; T. Draper; E. McSweegan; J. J. Halperin; M. S. Klempner; P. J. Krause; P. Mead; M. Morshed; R. Porwancher; J. D. Radolf; R. P. Smith; S. Sood; A. Weinstein; S. J. Wong; L. Zemel

doi:10.1056/NEJMra072023

A critical appraisal of "chronic lyme disease"

Henry M. Feder^*, Barbara J.B. Johnson, Susan O'Connell, Eugene D. Shapiro, Allen C. Steere, Gary P. Wormser, W. A. Agger, H. Artsob, P. Auwaerter, J. S. Dumler, J. S. Bakken, L. K. Bockenstedt, J. Green, R. J. Dattwyler, J. Munoz, R. B. Nadelman, I. Schwartz, T. Draper, E. McSweegan, J. J. HalperinM. S. Klempner, P. J. Krause, P. Mead, M. Morshed, R. Porwancher, J. D. Radolf, R. P. Smith, S. Sood, A. Weinstein, S. J. Wong, L. Zemel

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

501 Scopus citations

Abstract

"Chronic Lyme disease" is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease.

Original language	English
Pages (from-to)	1422
Number of pages	1
Journal	New England Journal of Medicine
Volume	357
Issue number	14
DOIs	https://doi.org/10.1056/NEJMra072023
State	Published - 4 Oct 2007

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10.1056/NEJMra072023

Cite this

Feder, H. M., Johnson, B. J. B., O'Connell, S., Shapiro, E. D., Steere, A. C., Wormser, G. P., Agger, W. A., Artsob, H., Auwaerter, P., Dumler, J. S., Bakken, J. S., Bockenstedt, L. K., Green, J., Dattwyler, R. J., Munoz, J., Nadelman, R. B., Schwartz, I., Draper, T., McSweegan, E., ... Zemel, L. (2007). A critical appraisal of "chronic lyme disease". New England Journal of Medicine, 357(14), 1422. https://doi.org/10.1056/NEJMra072023

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title = "A critical appraisal of {"}chronic lyme disease{"}",

abstract = "{"}Chronic Lyme disease{"} is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease.",

author = "Feder, {Henry M.} and Johnson, {Barbara J.B.} and Susan O'Connell and Shapiro, {Eugene D.} and Steere, {Allen C.} and Wormser, {Gary P.} and Agger, {W. A.} and H. Artsob and P. Auwaerter and Dumler, {J. S.} and Bakken, {J. S.} and Bockenstedt, {L. K.} and J. Green and Dattwyler, {R. J.} and J. Munoz and Nadelman, {R. B.} and I. Schwartz and T. Draper and E. McSweegan and Halperin, {J. J.} and Klempner, {M. S.} and Krause, {P. J.} and P. Mead and M. Morshed and R. Porwancher and Radolf, {J. D.} and Smith, {R. P.} and S. Sood and A. Weinstein and Wong, {S. J.} and L. Zemel",

year = "2007",

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Feder, HM, Johnson, BJB, O'Connell, S, Shapiro, ED, Steere, AC, Wormser, GP, Agger, WA, Artsob, H, Auwaerter, P, Dumler, JS, Bakken, JS, Bockenstedt, LK, Green, J, Dattwyler, RJ, Munoz, J, Nadelman, RB, Schwartz, I, Draper, T, McSweegan, E, Halperin, JJ, Klempner, MS, Krause, PJ, Mead, P, Morshed, M, Porwancher, R, Radolf, JD, Smith, RP, Sood, S, Weinstein, A, Wong, SJ & Zemel, L 2007, 'A critical appraisal of "chronic lyme disease"', New England Journal of Medicine, vol. 357, no. 14, pp. 1422. https://doi.org/10.1056/NEJMra072023

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AU - Steere, Allen C.

AU - Wormser, Gary P.

AU - Agger, W. A.

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AU - Auwaerter, P.

AU - Dumler, J. S.

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AU - Munoz, J.

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AU - Schwartz, I.

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AU - Klempner, M. S.

AU - Krause, P. J.

AU - Mead, P.

AU - Morshed, M.

AU - Porwancher, R.

AU - Radolf, J. D.

AU - Smith, R. P.

AU - Sood, S.

AU - Weinstein, A.

AU - Wong, S. J.

AU - Zemel, L.

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