TY - JOUR
T1 - A developmental atlas of rat mammary gland histology
AU - Masso-Welch, Patricia A.
AU - Darcy, Kathleen M.
AU - Stangle-Castor, Nannette C.
AU - Ip, Margot M.
PY - 2000
Y1 - 2000
N2 - The mammary gland is a dynamic tissue that undergoes epithelial expansion and invasion during puberty and cycles of branching and lobular morphogenesis, secretory differentiation, and regression during pregnancy, lactation, and involution. The alteration in the mammary gland epithelium during its postnatal differentiation is accompanied by changes in the multiple stromal cell types present in this complex tissue. The postnatal plasticity of the epithelium, endothelium, and stromal cells of the mammary gland may contribute to its susceptibility to carcinogenesis. The purpose of this review is to assist researchers in recognizing histological changes in the epithelium and stroma of the rat mammary gland throughout development.
AB - The mammary gland is a dynamic tissue that undergoes epithelial expansion and invasion during puberty and cycles of branching and lobular morphogenesis, secretory differentiation, and regression during pregnancy, lactation, and involution. The alteration in the mammary gland epithelium during its postnatal differentiation is accompanied by changes in the multiple stromal cell types present in this complex tissue. The postnatal plasticity of the epithelium, endothelium, and stromal cells of the mammary gland may contribute to its susceptibility to carcinogenesis. The purpose of this review is to assist researchers in recognizing histological changes in the epithelium and stroma of the rat mammary gland throughout development.
KW - Development
KW - Histology
KW - Mammary gland
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0034527151&partnerID=8YFLogxK
U2 - 10.1023/A:1026491221687
DO - 10.1023/A:1026491221687
M3 - Article
C2 - 11149571
AN - SCOPUS:0034527151
SN - 1083-3021
VL - 5
SP - 165
EP - 185
JO - Journal of Mammary Gland Biology and Neoplasia
JF - Journal of Mammary Gland Biology and Neoplasia
IS - 2
ER -