A developmental atlas of rat mammary gland histology

Patricia A. Masso-Welch, Kathleen M. Darcy, Nannette C. Stangle-Castor, Margot M. Ip

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


The mammary gland is a dynamic tissue that undergoes epithelial expansion and invasion during puberty and cycles of branching and lobular morphogenesis, secretory differentiation, and regression during pregnancy, lactation, and involution. The alteration in the mammary gland epithelium during its postnatal differentiation is accompanied by changes in the multiple stromal cell types present in this complex tissue. The postnatal plasticity of the epithelium, endothelium, and stromal cells of the mammary gland may contribute to its susceptibility to carcinogenesis. The purpose of this review is to assist researchers in recognizing histological changes in the epithelium and stroma of the rat mammary gland throughout development.

Original languageEnglish
Pages (from-to)165-185
Number of pages21
JournalJournal of Mammary Gland Biology and Neoplasia
Issue number2
StatePublished - 2000


  • Development
  • Histology
  • Mammary gland
  • Rat


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