A discussion of heat generation during a fever

Weidong Zhou*, Lance A. Liotta, Emanuel F. Petricoin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Fever can be caused by pathogen infection. We analyze the thermogenesis mechanism and reveal that heat is naturally generated during the immune system’s fight against pathogen infection. Particularly, the heat production by reactive oxygen species that originates in the respiratory burst significantly contributes to the fever development. This analysis can help address mechanisms of SARS-CoV-2 pathogenesis or provide a foundation for future mechanistic inquiries.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalCurrent Topics in Peptide and Protein Research
StatePublished - 2022
Externally publishedYes


  • SARS-CoV-2
  • fever
  • reactive oxygen species
  • respiratory burst
  • thermogenesis


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