A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies

Shilei Ding; Maxime Veillette; Mathieu Coutu; Jérémie Prévost; Louise Scharf; Pamela J. Bjorkman; Guido Ferrari; James E. Robinson; Christina Stürzel; Beatrice H. Hahn; Daniel Sauter; Frank Kirchhoff; George K. Lewis; Marzena Pazgier; Andrés Finzi

doi:10.1128/JVI.02779-15

A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies

Shilei Ding, Maxime Veillette, Mathieu Coutu, Jérémie Prévost, Louise Scharf, Pamela J. Bjorkman, Guido Ferrari, James E. Robinson, Christina Stürzel, Beatrice H. Hahn, Daniel Sauter, Frank Kirchhoff, George K. Lewis, Marzena Pazgier, Andrés Finzi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.

Original language	English
Pages (from-to)	2127-2134
Number of pages	8
Journal	Journal of Virology
Volume	90
Issue number	4
DOIs	https://doi.org/10.1128/JVI.02779-15
State	Published - 2016
Externally published	Yes

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Ding, S., Veillette, M., Coutu, M., Prévost, J., Scharf, L., Bjorkman, P. J., Ferrari, G., Robinson, J. E., Stürzel, C., Hahn, B. H., Sauter, D., Kirchhoff, F., Lewis, G. K., Pazgier, M., & Finzi, A. (2016). A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies. Journal of Virology, 90(4), 2127-2134. https://doi.org/10.1128/JVI.02779-15

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title = "A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies",

abstract = "Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.",

author = "Shilei Ding and Maxime Veillette and Mathieu Coutu and J{\'e}r{\'e}mie Pr{\'e}vost and Louise Scharf and Bjorkman, {Pamela J.} and Guido Ferrari and Robinson, {James E.} and Christina St{\"u}rzel and Hahn, {Beatrice H.} and Daniel Sauter and Frank Kirchhoff and Lewis, {George K.} and Marzena Pazgier and Andr{\'e}s Finzi",

note = "Publisher Copyright: {\textcopyright} 2016, American Society for Microbiology.",

year = "2016",

doi = "10.1128/JVI.02779-15",

language = "English",

volume = "90",

pages = "2127--2134",

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Ding, S, Veillette, M, Coutu, M, Prévost, J, Scharf, L, Bjorkman, PJ, Ferrari, G, Robinson, JE, Stürzel, C, Hahn, BH, Sauter, D, Kirchhoff, F, Lewis, GK, Pazgier, M & Finzi, A 2016, 'A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies', Journal of Virology, vol. 90, no. 4, pp. 2127-2134. https://doi.org/10.1128/JVI.02779-15

TY - JOUR

T1 - A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies

AU - Ding, Shilei

AU - Veillette, Maxime

AU - Coutu, Mathieu

AU - Prévost, Jérémie

AU - Scharf, Louise

AU - Bjorkman, Pamela J.

AU - Ferrari, Guido

AU - Robinson, James E.

AU - Stürzel, Christina

AU - Hahn, Beatrice H.

AU - Sauter, Daniel

AU - Kirchhoff, Frank

AU - Lewis, George K.

AU - Pazgier, Marzena

AU - Finzi, Andrés

PY - 2016

Y1 - 2016

N2 - Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.

AB - Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.

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U2 - 10.1128/JVI.02779-15

DO - 10.1128/JVI.02779-15

M3 - Article

C2 - 26637462

AN - SCOPUS:84958093132

SN - 0022-538X

VL - 90

SP - 2127

EP - 2134

JO - Journal of Virology

JF - Journal of Virology

IS - 4

ER -

A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies

Abstract

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