A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies

Shilei Ding; Maxime Veillette; Mathieu Coutu; Jérémie Prévost; Louise Scharf; Pamela J. Bjorkman; Guido Ferrari; James E. Robinson; Christina Stürzel; Beatrice H. Hahn; Daniel Sauter; Frank Kirchhoff; George K. Lewis; Marzena Pazgier; Andrés Finzi

doi:10.1128/JVI.02779-15

A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies

Shilei Ding
, Maxime Veillette
, Mathieu Coutu
, Jérémie Prévost
, Louise Scharf
, Pamela J. Bjorkman
, Guido Ferrari
, James E. Robinson
, Christina Stürzel
, Beatrice H. Hahn
, Daniel Sauter
, Frank Kirchhoff
, George K. Lewis
, Marzena Pazgier
, Andrés Finzi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.

Original language	English
Pages (from-to)	2127-2134
Number of pages	8
Journal	Journal of Virology
Volume	90
Issue number	4
DOIs	https://doi.org/10.1128/JVI.02779-15
State	Published - 2016
Externally published	Yes

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Ding, S., Veillette, M., Coutu, M., Prévost, J., Scharf, L., Bjorkman, P. J., Ferrari, G., Robinson, J. E., Stürzel, C., Hahn, B. H., Sauter, D., Kirchhoff, F., Lewis, G. K., Pazgier, M., & Finzi, A. (2016). A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies. Journal of Virology, 90(4), 2127-2134. https://doi.org/10.1128/JVI.02779-15

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title = "A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies",

abstract = "Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.",

author = "Shilei Ding and Maxime Veillette and Mathieu Coutu and J{\'e}r{\'e}mie Pr{\'e}vost and Louise Scharf and Bjorkman, \{Pamela J.\} and Guido Ferrari and Robinson, \{James E.\} and Christina St{\"u}rzel and Hahn, \{Beatrice H.\} and Daniel Sauter and Frank Kirchhoff and Lewis, \{George K.\} and Marzena Pazgier and Andr{\'e}s Finzi",

note = "Publisher Copyright: {\textcopyright} 2016, American Society for Microbiology.",

year = "2016",

doi = "10.1128/JVI.02779-15",

language = "English",

volume = "90",

pages = "2127--2134",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

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Ding, S, Veillette, M, Coutu, M, Prévost, J, Scharf, L, Bjorkman, PJ, Ferrari, G, Robinson, JE, Stürzel, C, Hahn, BH, Sauter, D, Kirchhoff, F, Lewis, GK, Pazgier, M & Finzi, A 2016, 'A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies', Journal of Virology, vol. 90, no. 4, pp. 2127-2134. https://doi.org/10.1128/JVI.02779-15

TY - JOUR

T1 - A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies

AU - Ding, Shilei

AU - Veillette, Maxime

AU - Coutu, Mathieu

AU - Prévost, Jérémie

AU - Scharf, Louise

AU - Bjorkman, Pamela J.

AU - Ferrari, Guido

AU - Robinson, James E.

AU - Stürzel, Christina

AU - Hahn, Beatrice H.

AU - Sauter, Daniel

AU - Kirchhoff, Frank

AU - Lewis, George K.

AU - Pazgier, Marzena

AU - Finzi, Andrés

PY - 2016

Y1 - 2016

N2 - Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.

AB - Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.

UR - https://www.scopus.com/pages/publications/84958093132

U2 - 10.1128/JVI.02779-15

DO - 10.1128/JVI.02779-15

M3 - Article

C2 - 26637462

AN - SCOPUS:84958093132

SN - 0022-538X

VL - 90

SP - 2127

EP - 2134

JO - Journal of Virology

JF - Journal of Virology

IS - 4

ER -

A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster a antibodies

Abstract

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