A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: Comparison with alzheimer’s disease

Constantin Bouras; Panteleimon Giannakopoulos; Paul F. Good; Amy Hsu; Patrick R. Hof; Daniel P. Perl

doi:10.1159/000112903

A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: Comparison with alzheimer’s disease

Constantin Bouras^*
, Panteleimon Giannakopoulos
, Paul F. Good
, Amy Hsu
, Patrick R. Hof
, Daniel P. Perl

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

We report a laser microprobe mass analysis of aluminum and iron content in the hippocampus and in the inferior temporal cortex in 2 cases of dementia pugilistica (DP), 4 cases of Alzheimer’s disease (AD), and 3 controls. There was a predominant accumulation of Al and Fe within neurofibrillary tangles (NFT) in both DP and AD cases. High levels of Al and Fe were also detected in the nuclei of NFT-free and NFT-containing neurons, as well as in neuropil probe sites in these cases. In both regions, NFT contained substantially higher levels of Al and Fe in DP compared to AD cases. These findings suggest the existence of an association between the deposition of Al and Fe and NFT formation, and support the possibility of a global dysregulation of Al and Fe transport in DP and AD.

Original language	English
Pages (from-to)	53-58
Number of pages	6
Journal	European Neurology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1159/000112903
State	Published - 1 Jan 1997

Keywords

Alzheimer’s disease
Dementia pugilistica
Laser microprobe mass analysis
Trace elements

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10.1159/000112903

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title = "A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: Comparison with alzheimer{\textquoteright}s disease",

abstract = "We report a laser microprobe mass analysis of aluminum and iron content in the hippocampus and in the inferior temporal cortex in 2 cases of dementia pugilistica (DP), 4 cases of Alzheimer{\textquoteright}s disease (AD), and 3 controls. There was a predominant accumulation of Al and Fe within neurofibrillary tangles (NFT) in both DP and AD cases. High levels of Al and Fe were also detected in the nuclei of NFT-free and NFT-containing neurons, as well as in neuropil probe sites in these cases. In both regions, NFT contained substantially higher levels of Al and Fe in DP compared to AD cases. These findings suggest the existence of an association between the deposition of Al and Fe and NFT formation, and support the possibility of a global dysregulation of Al and Fe transport in DP and AD.",

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T1 - A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica

T2 - Comparison with alzheimer’s disease

AU - Bouras, Constantin

AU - Giannakopoulos, Panteleimon

AU - Good, Paul F.

AU - Hsu, Amy

AU - Hof, Patrick R.

AU - Perl, Daniel P.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - We report a laser microprobe mass analysis of aluminum and iron content in the hippocampus and in the inferior temporal cortex in 2 cases of dementia pugilistica (DP), 4 cases of Alzheimer’s disease (AD), and 3 controls. There was a predominant accumulation of Al and Fe within neurofibrillary tangles (NFT) in both DP and AD cases. High levels of Al and Fe were also detected in the nuclei of NFT-free and NFT-containing neurons, as well as in neuropil probe sites in these cases. In both regions, NFT contained substantially higher levels of Al and Fe in DP compared to AD cases. These findings suggest the existence of an association between the deposition of Al and Fe and NFT formation, and support the possibility of a global dysregulation of Al and Fe transport in DP and AD.

AB - We report a laser microprobe mass analysis of aluminum and iron content in the hippocampus and in the inferior temporal cortex in 2 cases of dementia pugilistica (DP), 4 cases of Alzheimer’s disease (AD), and 3 controls. There was a predominant accumulation of Al and Fe within neurofibrillary tangles (NFT) in both DP and AD cases. High levels of Al and Fe were also detected in the nuclei of NFT-free and NFT-containing neurons, as well as in neuropil probe sites in these cases. In both regions, NFT contained substantially higher levels of Al and Fe in DP compared to AD cases. These findings suggest the existence of an association between the deposition of Al and Fe and NFT formation, and support the possibility of a global dysregulation of Al and Fe transport in DP and AD.

KW - Alzheimer’s disease

KW - Dementia pugilistica

KW - Laser microprobe mass analysis

KW - Trace elements

UR - https://www.scopus.com/pages/publications/0030832287

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DO - 10.1159/000112903

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JO - European Neurology

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IS - 1

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A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: Comparison with alzheimer’s disease

Abstract

Keywords

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