A left-handed solution to peptide inhibition of the p53-MDM2 interaction

Min Liu*, Marzena Pazgier, Changqing Li, Weirong Yuan, Chong Li, Wuyuan Lu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Throwing tumors a left-hook punch: The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror-image phage display identified a high-affinity D-peptide ligand of MDM2 (see structure) that could be developed into a potent and protease-resistant p53 activator with potential antitumor activity. (Figure Presented)

Original languageEnglish
Pages (from-to)3649-3652
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number21
DOIs
StatePublished - 10 May 2010
Externally publishedYes

Keywords

  • Antitumor agents
  • MDM2
  • P53
  • Protein structures
  • Protein-protein interactions

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