A low molecular weight antioxidant decreases weight and lowers tumor incidence

James B. Mitchell; Sandhya Xavier; Anne M. DeLuca; Anastasia L. Sowers; John A. Cook; Murali C. Krishna; Stephen M. Hahn; Angelo Russo

doi:10.1016/S0891-5849(02)01193-0

A low molecular weight antioxidant decreases weight and lowers tumor incidence

James B. Mitchell^*, Sandhya Xavier, Anne M. DeLuca, Anastasia L. Sowers, John A. Cook, Murali C. Krishna, Stephen M. Hahn, Angelo Russo

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Stable free radical nitroxides are potent antioxidants possessing superoxide dismutase- and catalase-mimetic activity that protect cells and animals against a variety of oxidative insults. Tempol, as a representative nitroxide, was evaluated for its influence on weight maintenance and spontaneous tumor incidence in C3H mice. Tempol administered in either the drinking water or food did not show any untoward effects and prevented animals from becoming obese. Tempol-treated animals' leptin levels were reduced. Long-term treatment with Tempol significantly decreased tumorigenesis when compared to controls (10 vs. 40%, respectively). Selected tissues from Tempol-treated animals exhibited elevated levels of mitochrondrial uncoupling protein-2 (UCP-2) and HSP70. The present data suggest that nitroxides upregulate UCP-2, obviate weight gain, and decrease age-related spontaneous tumor incidence. As a class, nitroxides may provide overall health benefits by contributing to decreased obesity and tumor incidence.

Original language	English
Pages (from-to)	93-102
Number of pages	10
Journal	Free Radical Biology and Medicine
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/S0891-5849(02)01193-0
State	Published - 1 Jan 2003

Keywords

Aging
Antioxidant
Carcinogenesis
Free radicals
Nitroxide
Obesity
Oxidative stress
Uncoupling protein

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10.1016/S0891-5849(02)01193-0

Cite this

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title = "A low molecular weight antioxidant decreases weight and lowers tumor incidence",

abstract = "Stable free radical nitroxides are potent antioxidants possessing superoxide dismutase- and catalase-mimetic activity that protect cells and animals against a variety of oxidative insults. Tempol, as a representative nitroxide, was evaluated for its influence on weight maintenance and spontaneous tumor incidence in C3H mice. Tempol administered in either the drinking water or food did not show any untoward effects and prevented animals from becoming obese. Tempol-treated animals' leptin levels were reduced. Long-term treatment with Tempol significantly decreased tumorigenesis when compared to controls (10 vs. 40%, respectively). Selected tissues from Tempol-treated animals exhibited elevated levels of mitochrondrial uncoupling protein-2 (UCP-2) and HSP70. The present data suggest that nitroxides upregulate UCP-2, obviate weight gain, and decrease age-related spontaneous tumor incidence. As a class, nitroxides may provide overall health benefits by contributing to decreased obesity and tumor incidence.",

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author = "Mitchell, {James B.} and Sandhya Xavier and DeLuca, {Anne M.} and Sowers, {Anastasia L.} and Cook, {John A.} and Krishna, {Murali C.} and Hahn, {Stephen M.} and Angelo Russo",

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AU - Mitchell, James B.

AU - Xavier, Sandhya

AU - DeLuca, Anne M.

AU - Sowers, Anastasia L.

AU - Cook, John A.

AU - Krishna, Murali C.

AU - Hahn, Stephen M.

AU - Russo, Angelo

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Stable free radical nitroxides are potent antioxidants possessing superoxide dismutase- and catalase-mimetic activity that protect cells and animals against a variety of oxidative insults. Tempol, as a representative nitroxide, was evaluated for its influence on weight maintenance and spontaneous tumor incidence in C3H mice. Tempol administered in either the drinking water or food did not show any untoward effects and prevented animals from becoming obese. Tempol-treated animals' leptin levels were reduced. Long-term treatment with Tempol significantly decreased tumorigenesis when compared to controls (10 vs. 40%, respectively). Selected tissues from Tempol-treated animals exhibited elevated levels of mitochrondrial uncoupling protein-2 (UCP-2) and HSP70. The present data suggest that nitroxides upregulate UCP-2, obviate weight gain, and decrease age-related spontaneous tumor incidence. As a class, nitroxides may provide overall health benefits by contributing to decreased obesity and tumor incidence.

AB - Stable free radical nitroxides are potent antioxidants possessing superoxide dismutase- and catalase-mimetic activity that protect cells and animals against a variety of oxidative insults. Tempol, as a representative nitroxide, was evaluated for its influence on weight maintenance and spontaneous tumor incidence in C3H mice. Tempol administered in either the drinking water or food did not show any untoward effects and prevented animals from becoming obese. Tempol-treated animals' leptin levels were reduced. Long-term treatment with Tempol significantly decreased tumorigenesis when compared to controls (10 vs. 40%, respectively). Selected tissues from Tempol-treated animals exhibited elevated levels of mitochrondrial uncoupling protein-2 (UCP-2) and HSP70. The present data suggest that nitroxides upregulate UCP-2, obviate weight gain, and decrease age-related spontaneous tumor incidence. As a class, nitroxides may provide overall health benefits by contributing to decreased obesity and tumor incidence.

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KW - Carcinogenesis

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KW - Nitroxide

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KW - Oxidative stress

KW - Uncoupling protein

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