A model for signal-relay adaptation in Dictyostelium discoideum. II. Analytical and numerical results

Hans G. Othmer; Peter B. Monk; Paul E. Rapp

doi:10.1016/0025-5564(85)90092-6

A model for signal-relay adaptation in Dictyostelium discoideum. II. Analytical and numerical results

Hans G. Othmer^*, Peter B. Monk, Paul E. Rapp

^*Corresponding author for this work

Military and Emergency Medicine

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10 Scopus citations

Abstract

In paper I we examined several schemes for the activation of adenylate cyclase in Dictyostelium discoideum and showed that they do not exhibit adaptation in the sense used there. In this paper, we introduce several schemes in which internal calcium acts as an inhibitor of adenylate cyclase, and analyze the dynamics of the complete network given in the proceeding paper using these schemes. We show that this network reproduces much of the experimentally observed behavior.

Original language	English
Pages (from-to)	79-139
Number of pages	61
Journal	Mathematical Biosciences
Volume	77
Issue number	1-2
DOIs	https://doi.org/10.1016/0025-5564(85)90092-6
State	Published - Dec 1985

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10.1016/0025-5564(85)90092-6

Cite this

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title = "A model for signal-relay adaptation in Dictyostelium discoideum. II. Analytical and numerical results",

abstract = "In paper I we examined several schemes for the activation of adenylate cyclase in Dictyostelium discoideum and showed that they do not exhibit adaptation in the sense used there. In this paper, we introduce several schemes in which internal calcium acts as an inhibitor of adenylate cyclase, and analyze the dynamics of the complete network given in the proceeding paper using these schemes. We show that this network reproduces much of the experimentally observed behavior.",

author = "Othmer, {Hans G.} and Monk, {Peter B.} and Rapp, {Paul E.}",

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AU - Othmer, Hans G.

AU - Monk, Peter B.

AU - Rapp, Paul E.

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Y1 - 1985/12

N2 - In paper I we examined several schemes for the activation of adenylate cyclase in Dictyostelium discoideum and showed that they do not exhibit adaptation in the sense used there. In this paper, we introduce several schemes in which internal calcium acts as an inhibitor of adenylate cyclase, and analyze the dynamics of the complete network given in the proceeding paper using these schemes. We show that this network reproduces much of the experimentally observed behavior.

AB - In paper I we examined several schemes for the activation of adenylate cyclase in Dictyostelium discoideum and showed that they do not exhibit adaptation in the sense used there. In this paper, we introduce several schemes in which internal calcium acts as an inhibitor of adenylate cyclase, and analyze the dynamics of the complete network given in the proceeding paper using these schemes. We show that this network reproduces much of the experimentally observed behavior.

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