A model of recovery from inhalation injury and cutaneous burn in ambulatory swine

David M. Burmeister, Matthew K. McIntyre, Brendan Beely, Bryan Jordan, Kerfoot P. Walker, James K. Aden, Andriy Batchinsky, Kevin K. Chung, Leopoldo C. Cancio, Robert J. Christy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Inhalation injury commonly accompanies thermal injury, increasing the likelihood of mortality and multiple organ dysfunction (MOD). Large animal models have given important insight into the pathophysiology of this injury; however recapitulating late MOD has remained difficult. The current report describes experiments using a smoke inhalation and burn model, with follow-up of ambulatory swine for 14 days with bronchoscopy, CT scanning, and bronchoalveolar lavage fluid (BALF)/blood collection. Clinically, animals cleared airway damage in the first several days after-injury. This was mirrored with erythematous airways on day 2 after-injury, which resolved by the end of the experiment, as did parenchymal damage seen on CT. An initial rise in the protein content of BALF immediately after-injury was followed by a dramatic increase in the concentration of leukocytes. Circulating neutrophils increased while lymphocytes decreased; both correlated with cell counts in BALF. IL8 levels in BALF increased 30-fold and remained elevated throughout the experiment. IL1ra increased circulation immediately after-injury, and afterwards in BALF. Other cytokines (TNFα, IL12) transiently increased in BALF (and decreased in circulation) on day 2. Taken together, these results display a remarkable capability for the lungs to recover in the absence of intubation, with further evidence of the role of cytokines such as IL8 and IL1ra. The possible exacerbating effects of clinical practices such as ventilation and bronchoscopies should be considered.

Original languageEnglish
Pages (from-to)1295-1305
Number of pages11
Issue number6
StatePublished - Sep 2017
Externally publishedYes


  • Burns
  • Cytokines
  • Inhalation injury
  • Intubation
  • Leukocytes
  • Swine


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