A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation

Myeongji Kim; Maryam Mahmood; Lynn L Estes; John W Wilson; Nathaniel J Martin; Joseph E Marcus; Ankit Mittal; Casey R O'Connell; Aditya Shah

doi:10.1186/s13054-024-05101-z

A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation

Myeongji Kim, Maryam Mahmood, Lynn L Estes, John W Wilson, Nathaniel J Martin, Joseph E Marcus, Ankit Mittal, Casey R O'Connell, Aditya Shah

Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.

Original language	English
Pages (from-to)	326
Journal	Critical Care
Volume	28
Issue number	1
DOIs	https://doi.org/10.1186/s13054-024-05101-z
State	Published - 4 Oct 2024

Keywords

Humans
Extracorporeal Membrane Oxygenation/methods
Critical Illness/therapy
Anti-Infective Agents/therapeutic use
Adult

Access to Document

10.1186/s13054-024-05101-z

Cite this

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title = "A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation",

abstract = "The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.",

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AU - Kim, Myeongji

AU - Mahmood, Maryam

AU - Estes, Lynn L

AU - Wilson, John W

AU - Martin, Nathaniel J

AU - Marcus, Joseph E

AU - Mittal, Ankit

AU - O'Connell, Casey R

AU - Shah, Aditya

PY - 2024/10/4

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N2 - The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.

AB - The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.

KW - Humans

KW - Extracorporeal Membrane Oxygenation/methods

KW - Critical Illness/therapy

KW - Anti-Infective Agents/therapeutic use

KW - Adult

U2 - 10.1186/s13054-024-05101-z

DO - 10.1186/s13054-024-05101-z

M3 - Review article

C2 - 39367501

SN - 1364-8535

VL - 28

SP - 326

JO - Critical Care

JF - Critical Care

IS - 1

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