A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation

Myeongji Kim; Maryam Mahmood; Lynn L. Estes; John W. Wilson; Nathaniel J. Martin; Joseph E. Marcus; Ankit Mittal; Casey R. O’Connell; Aditya Shah

doi:10.1186/s13054-024-05101-z

A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation

Myeongji Kim^*, Maryam Mahmood, Lynn L. Estes, John W. Wilson, Nathaniel J. Martin, Joseph E. Marcus, Ankit Mittal, Casey R. O’Connell, Aditya Shah

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.

Original language	English
Article number	326
Journal	Critical Care
Volume	28
Issue number	1
DOIs	https://doi.org/10.1186/s13054-024-05101-z
State	Published - Dec 2024
Externally published	Yes

Keywords

Antimicrobial dosing
Extracorporeal membrane oxygenation
Pharmacokinetics
Therapeutic drug monitoring

Access to Document

10.1186/s13054-024-05101-z

Cite this

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title = "A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation",

abstract = "The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.",

keywords = "Antimicrobial dosing, Extracorporeal membrane oxygenation, Pharmacokinetics, Therapeutic drug monitoring",

author = "Myeongji Kim and Maryam Mahmood and Estes, {Lynn L.} and Wilson, {John W.} and Martin, {Nathaniel J.} and Marcus, {Joseph E.} and Ankit Mittal and O{\textquoteright}Connell, {Casey R.} and Aditya Shah",

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AU - Kim, Myeongji

AU - Mahmood, Maryam

AU - Estes, Lynn L.

AU - Wilson, John W.

AU - Martin, Nathaniel J.

AU - Marcus, Joseph E.

AU - Mittal, Ankit

AU - O’Connell, Casey R.

AU - Shah, Aditya

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/12

Y1 - 2024/12

N2 - The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.

AB - The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.

KW - Antimicrobial dosing

KW - Extracorporeal membrane oxygenation

KW - Pharmacokinetics

KW - Therapeutic drug monitoring

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DO - 10.1186/s13054-024-05101-z

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AN - SCOPUS:85205762749

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