A new and safe mode of ventilation for interventional pulmonary medicine: The ease of nasal superimposed high frequency jet ventilation

Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis*, Haidong Huang, Yan Gao Man, Stella Laskou, Charilaos Koulouris, Dimitris Giannakidis, Stylianos Mantalobas, Maria C. Florou, Aikaterini Amaniti, Michael Steinheimer, Anil Sinha, Lutz Freitag, J. Francis Turner, Robert Browning, Thomas Vogl, Andrei Roman, Naim Benhassen, Isaak Kesisoglou, Konstantinos Sapalidis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in diagnostic pulmonary medicine. The method of sedation and ventilation is very important in order to avoid or handle with success complications. Proper respiration during pulmonary (or other interventional) procedures is a key factor. Apart from the proper sedation method we have to choose the proper ventilation method which decides respiratory movement. Superimposed high-frequency jet ventilation (SHFJV) is supposed to be safe and effective in clinical practice. Although this perception is commonly accepted, there is no study proving its safety on the basic of reliable data. We analyzed the data of 100 patients in different interventional settings (bronchoscopy with or without navigational approach, left atrial appendage closure (LAAC) or intracardiac catheterization) using nasal SHFJV. Mainly analyzed were capillary ABG-Data at the beginning and end of the intervention under sedation. The aim was to analyze if a risk scenario for the patient by using the nasal SHFJV can be derived by measuring the changes of pCO2, pO2, cBase Excess, cHCO3 and PH. Due to our data we conclude that this method of ventilation can be easily and safely used in interventional medicine for patients with all kind of comorbidities such as; chronic respiratory disease, lung cancer, interstitial lung disease, structural heart disease and heart failure.

Original languageEnglish
Pages (from-to)816-833
Number of pages18
JournalJournal of Cancer
Issue number5
StatePublished - 2018
Externally publishedYes


  • Bronchoscopy
  • Conebeam computertomography
  • Endobronchial navigation
  • Endobronchial ultrasound
  • Interventional medicine
  • Jet-ventilation
  • Lung cancer
  • Minimal-invasive techniques


Dive into the research topics of 'A new and safe mode of ventilation for interventional pulmonary medicine: The ease of nasal superimposed high frequency jet ventilation'. Together they form a unique fingerprint.

Cite this