@article{00954cd787244785b5d73180c62de90b,
title = "A novel association between sinus node dysfunction and an SCN5A variant presenting as persistent symptomatic bradycardia in a young adult",
keywords = "Atrial flutter, Corrected sinus node recovery time, Electrophysiology study, Intrinsic heart rate, SCN5A gene variant, Sinoatrial conduction time, Sinus node dysfunction, Symptomatic sinus bradycardia",
author = "Adam Kisling and Seth Klusewitz and Austin Pagani and Mark Haigney and Matthew Needleman",
note = "Funding Information: Current theories of sinus node automaticity include a contribution from a “voltage clock” driven by the inward “funny current” If and a contribution from a “calcium clock” driven by spontaneous calcium release from the sarcoplasmic reticulum with inward sodium-calcium exchange resulting in membrane depolarization.15 More recent data demonstrated that the spontaneous beating rate of human sinus nodal tissue is depressed by tetrodotoxin, a specific inhibitor of neuronal and, to a lesser extent, cardiac sodium channels.5 The apparent depression of sinus node automaticity associated with loss-of-function variants in SCN5A, as seen in this patient, supports the heterodoxical notion the cardiac sodium channels play a role in SA nodal automaticity.The opinions and assertions expressed herein are those of the author(s) and do not reflect the official policy or position of the Uniformed Services University of the Health Sciences or the Department of Defense. The opinions and assertions herein are those of the author(s) and do not reflect the official policy or position of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Partial support was received from award HU00011920029 from Defense Health Agency to the Military Cardiovascular Outcomes Research program, Uniformed Services University, Bethesda, MD. The authors have no conflicts to disclose.",
year = "2023",
month = sep,
doi = "10.1016/j.hrcr.2023.06.017",
language = "English",
volume = "9",
pages = "662--666",
journal = "HeartRhythm Case Reports",
issn = "2214-0271",
number = "9",
}