TY - JOUR
T1 - A population-based case-control study of the relationship between cigarette smoking and nasopharyngeal cancer (United States)
AU - Zhu, Kangmin
AU - Levine, Robert S.
AU - Brann, Edward A.
AU - Gnepp, Douglas R.
AU - Baum, Marianna K.
PY - 1995/11
Y1 - 1995/11
N2 - This case-control investigation, based on the Selected Cancers Study, assesses the association between cigarette smoking and nasopharyngeal cancer, a relatively rare neoplasm in the United States. Men who were diagnosed pathologically with nasopharyngeal cancer during 1984-88 were included as cases in the analysis if they were 15 to 39 years old in 1968, and lived in the areas covered by eight cancer registries in the US (n=113). Control men were selected by random-digit telephone dialing (n=1,910). Using logistic regression analysis with adjustment for potential confounding factors, it was found that relative to nonsmokers, the risks of nasopharyngeal cancer were 2.3 (95 percent confidence interval [CI]=1.3-4.0) and 1.4 (CI=0.8-2.6) for former and current smokers, respectively. Using pack-years as a measure, adjusted odds ratio (OR) estimates were 1.3, 1.8, 2.5, and 3.9 for smoking for less than 15, 15-29, 30-44, and 45 or more pack-years, respectively. When squamous cell carcinoma was used as an outcome, the smoking/nasopharyngeal-cancer association became stronger. The analysis did not show interactions between smoking and alcohol consumption, or prior nasal diseases. The results of this study suggest that cigarette smoking may be related to the occurrence of nasopharyngeal cancer (especially squamous cell carcinoma) among US men.
AB - This case-control investigation, based on the Selected Cancers Study, assesses the association between cigarette smoking and nasopharyngeal cancer, a relatively rare neoplasm in the United States. Men who were diagnosed pathologically with nasopharyngeal cancer during 1984-88 were included as cases in the analysis if they were 15 to 39 years old in 1968, and lived in the areas covered by eight cancer registries in the US (n=113). Control men were selected by random-digit telephone dialing (n=1,910). Using logistic regression analysis with adjustment for potential confounding factors, it was found that relative to nonsmokers, the risks of nasopharyngeal cancer were 2.3 (95 percent confidence interval [CI]=1.3-4.0) and 1.4 (CI=0.8-2.6) for former and current smokers, respectively. Using pack-years as a measure, adjusted odds ratio (OR) estimates were 1.3, 1.8, 2.5, and 3.9 for smoking for less than 15, 15-29, 30-44, and 45 or more pack-years, respectively. When squamous cell carcinoma was used as an outcome, the smoking/nasopharyngeal-cancer association became stronger. The analysis did not show interactions between smoking and alcohol consumption, or prior nasal diseases. The results of this study suggest that cigarette smoking may be related to the occurrence of nasopharyngeal cancer (especially squamous cell carcinoma) among US men.
KW - Males
KW - United States
KW - nasopharyngeal cancer
KW - smoking
KW - squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=0028857048&partnerID=8YFLogxK
U2 - 10.1007/BF00054158
DO - 10.1007/BF00054158
M3 - Article
C2 - 8580298
AN - SCOPUS:0028857048
SN - 0957-5243
VL - 6
SP - 507
EP - 512
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 6
ER -