A potential role for nitric oxide in myocardial stunning

B. G. Hattler; J. Gorcsan; N. Shah; C. V. Oddis; T. R. Billiar; R. L. Simmons; M. S. Finkel

doi:10.1111/jocs.1994.9.3s.425

A potential role for nitric oxide in myocardial stunning

B. G. Hattler^*, J. Gorcsan, N. Shah, C. V. Oddis, T. R. Billiar, R. L. Simmons, M. S. Finkel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Nitric oxide (NO) production by the human heart has been demonstrated in patients undergoing cardiac surgery. Similar to what has been described in other species, a basal production of NO by the human heart is seen (126 ± 42 pmol/min per gram). Following reperfusion, at the end of the procedure, the level of NO production increases significantly reaching concentrations of 1430 ± 330 pmol/min per gram. Increased activity for the enzyme NO synthase (NOS) (8.0 ± 1.2 pmol/mg prebypass vs 26.4 ± 4.8 pmol/mg postbypass) coincides with changes in NO production and occurs at a time when myocardial stunning is clinically detectable. The significance of these findings is discussed and suggest a role for NO in the pathophysiology of myocardial stunning.

Original language	English
Pages (from-to)	425-429
Number of pages	5
Journal	Journal of Cardiac Surgery
Volume	9
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1111/jocs.1994.9.3s.425
State	Published - 1994
Externally published	Yes

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title = "A potential role for nitric oxide in myocardial stunning",

abstract = "Nitric oxide (NO) production by the human heart has been demonstrated in patients undergoing cardiac surgery. Similar to what has been described in other species, a basal production of NO by the human heart is seen (126 ± 42 pmol/min per gram). Following reperfusion, at the end of the procedure, the level of NO production increases significantly reaching concentrations of 1430 ± 330 pmol/min per gram. Increased activity for the enzyme NO synthase (NOS) (8.0 ± 1.2 pmol/mg prebypass vs 26.4 ± 4.8 pmol/mg postbypass) coincides with changes in NO production and occurs at a time when myocardial stunning is clinically detectable. The significance of these findings is discussed and suggest a role for NO in the pathophysiology of myocardial stunning.",

author = "Hattler, {B. G.} and J. Gorcsan and N. Shah and Oddis, {C. V.} and Billiar, {T. R.} and Simmons, {R. L.} and Finkel, {M. S.}",

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language = "English",

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T1 - A potential role for nitric oxide in myocardial stunning

AU - Hattler, B. G.

AU - Gorcsan, J.

AU - Shah, N.

AU - Oddis, C. V.

AU - Billiar, T. R.

AU - Simmons, R. L.

AU - Finkel, M. S.

PY - 1994

Y1 - 1994

N2 - Nitric oxide (NO) production by the human heart has been demonstrated in patients undergoing cardiac surgery. Similar to what has been described in other species, a basal production of NO by the human heart is seen (126 ± 42 pmol/min per gram). Following reperfusion, at the end of the procedure, the level of NO production increases significantly reaching concentrations of 1430 ± 330 pmol/min per gram. Increased activity for the enzyme NO synthase (NOS) (8.0 ± 1.2 pmol/mg prebypass vs 26.4 ± 4.8 pmol/mg postbypass) coincides with changes in NO production and occurs at a time when myocardial stunning is clinically detectable. The significance of these findings is discussed and suggest a role for NO in the pathophysiology of myocardial stunning.

AB - Nitric oxide (NO) production by the human heart has been demonstrated in patients undergoing cardiac surgery. Similar to what has been described in other species, a basal production of NO by the human heart is seen (126 ± 42 pmol/min per gram). Following reperfusion, at the end of the procedure, the level of NO production increases significantly reaching concentrations of 1430 ± 330 pmol/min per gram. Increased activity for the enzyme NO synthase (NOS) (8.0 ± 1.2 pmol/mg prebypass vs 26.4 ± 4.8 pmol/mg postbypass) coincides with changes in NO production and occurs at a time when myocardial stunning is clinically detectable. The significance of these findings is discussed and suggest a role for NO in the pathophysiology of myocardial stunning.

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AN - SCOPUS:0028198880

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VL - 9

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JO - Journal of Cardiac Surgery

JF - Journal of Cardiac Surgery

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ER -

A potential role for nitric oxide in myocardial stunning

Abstract

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