A preliminary three-dimensional structure of angiogenin

K A Palmer, H A Scheraga, J F Riordan, B L Vallee

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60 Scopus citations


A preliminary three-dimensional structure of angiogenin has been computed, based on its homology to bovine pancreatic ribonuclease A. A standard-geometry structure of ribonuclease was first obtained from its x-ray coordinates. The fit of the backbone of angiogenin to that of ribonuclease was then optimized by taking account of amino acid deletions and by minimizing its conformational energy-plus-a-penalty distance function constraining its backbone to that of ribonuclease. Side-chain and backbone dihedral angles were allowed to vary throughout the cycles of energy minimization. In the last stages of minimization, the penalty distance function was removed. A low-energy structure resembling ribonuclease was obtained.

Original languageEnglish
Pages (from-to)1965-9
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number7
StatePublished - Apr 1986


  • Humans
  • Models, Molecular
  • Neoplasm Proteins
  • Protein Conformation
  • Ribonuclease, Pancreatic
  • Ribonucleases
  • Software
  • Thermodynamics


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