A Rare Cause of Dysphagia and Weight Loss

Janelle B. Gyorffy*, Johanna Marowske, John Gancayco

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Mixed connective tissue disease (MCTD) is a rare connective tissue disorder with clinical features that overlap with systemic lupus erythematous, systemic sclerosis, and polymyositis. We report the case of a patient who presented with dysphagia, 25-lb weight loss, difficulty opening her mouth, and joint pain. Dysphagia workup showed a normal barium swallow and normal-appearing EGD but esophageal manometry consistent with severe dysmotility. Through further laboratory and imaging studies, the patient met the diagnostic criteria for MCTD. She had marked improvement in her dysphagia with steroids, biologic therapy, and intravenous immunoglobulin.

Original languageEnglish
Pages (from-to)640-645
Number of pages6
JournalCase Reports in Gastroenterology
Issue number3
StatePublished - 1 Sep 2018
Externally publishedYes


  • Esophageal dysmotility
  • High-resolution esophageal manometry
  • Mixed connective tissue disease


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