A rich array of prostate cancer molecular biomarkers: Opportunities and challenges

Indu Kohaar*, Gyorgy Petrovics, Shiv Srivastava

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations

Abstract

Prostate cancer is the most prevalent non-skin cancer in men and is the leading cause of cancer-related death. Early detection of prostate cancer is largely determined by a widely used prostate specific antigen (PSA) blood test and biopsy is performed for definitive diagnosis. Prostate cancer is asymptomatic in the early stage of the disease, comprises of diverse clinico-pathologic and progression features, and is characterized by a large subset of the indolent cancer type. Therefore, it is critical to develop an individualized approach for early detection, disease stratification (indolent vs. aggressive), and prediction of treatment response for prostate cancer. There has been remarkable progress in prostate cancer biomarker discovery, largely through advancements in genomic technologies. A rich array of prostate cancer diagnostic and prognostic tests has emerged for serum (4K, phi), urine (Progensa, T2-ERG, ExoDx, SelectMDx), and tumor tissue (ConfirmMDx, Prolaris, Oncoytype DX, Decipher). The development of these assays has created new opportunities for improving prostate cancer diagnosis, prognosis, and treatment decisions. While opening exciting opportunities, these developments also pose unique challenges in terms of selecting and incorporating these assays into the continuum of prostate cancer patient care.

Original languageEnglish
Article number1813
JournalInternational Journal of Molecular Sciences
Volume20
Issue number8
DOIs
StatePublished - 2 Apr 2019
Externally publishedYes

Keywords

  • Diagnosis
  • Molecular biomarkers
  • Prognosis
  • Prostate cancer

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