A role for RIO kinases in the crosshair of cancer research and therapy

Morteza Ghandadi*, Albert Dobi, Sanjay V. Malhotra

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


RIO (right open reading frame) family of kinases including RIOK1, RIOK2 and RIOK3 are known for their role in the ribosomal biogenesis. Dysfunction of RIO kinases have been implicated in malignancies, including acute myeloid leukemia, glioma, breast, colorectal, lung and prostatic adenocarcinoma suggesting RIO kinases as potential targets in cancer. In vitro, in vivo and clinical studies have demonstrated that RIO kinases are overexpressed in various types of cancers suggesting important roles in tumorigenesis, especially in metastasis. In the context of malignancies, RIO kinases are involved in cancer-promoting pathways including AKT/mTOR, RAS, p53 and NF-κB and cell cycle regulation. Here we review the role of RIO kinases in cancer development emphasizing their potential as therapeutic target and encouraging further development and investigation of inhibitors in the context of cancer.

Original languageEnglish
Article number189100
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Issue number3
StatePublished - May 2024
Externally publishedYes


  • Cancer
  • Metastasis
  • Multidrug resistance
  • RIOK1
  • RIOK2
  • RIOK3


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