TY - JOUR
T1 - A serological study of Chikungunya virus transmission in Yogyakarta, Indonesia
T2 - Evidence for the first outbreak since 1982
AU - Porter, Kevin R.
AU - Tan, Ratna
AU - Istary, Yunry
AU - Suharyono, Wuryadi
AU - Sutaryo,
AU - Widjaja, Susana
AU - Ma'Roef, Chairin
AU - Listiyaningsih, Erlin
AU - Kosasih, Herman
AU - Hueston, Linda
AU - McArdle, James
AU - Juffrie, Mohammad
PY - 2004/6
Y1 - 2004/6
N2 - A study of epidemic transmission of Chikungunya virus (CHIK) was initiated in April 1999 in Yogyakarta, Indonesia. Three hundred seventeen volunteers from three kelurahans (sub-districts) were recruited. Anti-CHIK IgG antibodies were detected in 68% to 74% of cases and 28% to 32% of controls. In the kelurahan with no reported CHIK illness, 29% of cases and 28% of controls had anti-CHIK IgG antibodies. None of these cases demonstrated anti-CHIK IgM antibodies. In the two kelurahans with disease activity, anti-CHIK IgM antibodies were detected in 3% to 36% of cases, with the highest percentage from the kelurahan with recently reported cases. Ten percent of controls from Gowok had anti-CHIK IgM detected in their serum. Twelve acutely ill volunteers were later included from the kelurahan Pilahan for virus identification. Samples from two volunteers were culture- and RT-PCR-positive for CHIK. This is the first documentation of epidemic transmission of CHIK in Indonesia since 1982.
AB - A study of epidemic transmission of Chikungunya virus (CHIK) was initiated in April 1999 in Yogyakarta, Indonesia. Three hundred seventeen volunteers from three kelurahans (sub-districts) were recruited. Anti-CHIK IgG antibodies were detected in 68% to 74% of cases and 28% to 32% of controls. In the kelurahan with no reported CHIK illness, 29% of cases and 28% of controls had anti-CHIK IgG antibodies. None of these cases demonstrated anti-CHIK IgM antibodies. In the two kelurahans with disease activity, anti-CHIK IgM antibodies were detected in 3% to 36% of cases, with the highest percentage from the kelurahan with recently reported cases. Ten percent of controls from Gowok had anti-CHIK IgM detected in their serum. Twelve acutely ill volunteers were later included from the kelurahan Pilahan for virus identification. Samples from two volunteers were culture- and RT-PCR-positive for CHIK. This is the first documentation of epidemic transmission of CHIK in Indonesia since 1982.
UR - http://www.scopus.com/inward/record.url?scp=4544223535&partnerID=8YFLogxK
M3 - Article
C2 - 15691147
AN - SCOPUS:4544223535
SN - 0125-1562
VL - 35
SP - 408
EP - 415
JO - Southeast Asian Journal of Tropical Medicine and Public Health
JF - Southeast Asian Journal of Tropical Medicine and Public Health
IS - 2
ER -