TY - JOUR
T1 - A tale of four studies
T2 - HIV vaccine immunogenicity and efficacy in clinical trials
AU - Zolla-Pazner, Susan
AU - Michael, Nelson L.
AU - Kim, Jerome H.
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/7
Y1 - 2021/7
N2 - The advanced-phase HIV prevention vaccine trials done in South Africa (HVTN 702) and in Thailand (RV144), which both investigated canarypox vectors and adjuvanted gp120 proteins, gave rise to different results. The South African trial did not find vaccine efficacy, whereas the Thai trial had modest, but statistically significant, success with the modified intention-to-treat analysis prespecified in the protocols of both studies. An understanding of the differences between the studies is required to avoid the possible, but erroneous, conclusion that the results from the South African trial negatively affect the results of the Thai trial.
AB - The advanced-phase HIV prevention vaccine trials done in South Africa (HVTN 702) and in Thailand (RV144), which both investigated canarypox vectors and adjuvanted gp120 proteins, gave rise to different results. The South African trial did not find vaccine efficacy, whereas the Thai trial had modest, but statistically significant, success with the modified intention-to-treat analysis prespecified in the protocols of both studies. An understanding of the differences between the studies is required to avoid the possible, but erroneous, conclusion that the results from the South African trial negatively affect the results of the Thai trial.
UR - http://www.scopus.com/inward/record.url?scp=85108849112&partnerID=8YFLogxK
U2 - 10.1016/S2352-3018(21)00073-4
DO - 10.1016/S2352-3018(21)00073-4
M3 - Review article
C2 - 34029515
AN - SCOPUS:85108849112
SN - 2352-3018
VL - 8
SP - e449-e452
JO - The Lancet HIV
JF - The Lancet HIV
IS - 7
ER -