A +TIP for a smooth trip

Xin Xiang*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations

Abstract

Is there a cellular mechanism for preventing a depolymerizing microtubule track from "slipping out from under" its cargo? A recent study in budding yeast indicates that when a chromosome is transported to the minus end of a spindle microtubule, its kinetochore-bound microtubule plus end-tracking protein (+TIP) Stu2 may move to the plus end to promote rescue; i.e., to switch the depolymerizing end to a polymerizing end. The possibility that other +TIPs may play a similar role in sustaining a microtubule track during vesicular transport deserves investigation.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalJournal of Cell Biology
Volume172
Issue number5
DOIs
StatePublished - 27 Feb 2006

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