Abstract
Is there a cellular mechanism for preventing a depolymerizing microtubule track from "slipping out from under" its cargo? A recent study in budding yeast indicates that when a chromosome is transported to the minus end of a spindle microtubule, its kinetochore-bound microtubule plus end-tracking protein (+TIP) Stu2 may move to the plus end to promote rescue; i.e., to switch the depolymerizing end to a polymerizing end. The possibility that other +TIPs may play a similar role in sustaining a microtubule track during vesicular transport deserves investigation.
Original language | English |
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Pages (from-to) | 651-654 |
Number of pages | 4 |
Journal | Journal of Cell Biology |
Volume | 172 |
Issue number | 5 |
DOIs | |
State | Published - 27 Feb 2006 |