A Yorkshire swine (Sus scrofa domesticus) model for nerve regeneration and ischemia based on the sciatic nerve and femoral artery

Sarah E. Kinsley; Stephen D. Fernicola; Marvin E. Dingle; Milfred S. Williams; Jody M. Richardson; Dennis Taylor; Jaira F. de Vasconcellos; Timothy R. Malone; Matthew R. Blattner; Jonathan K. Smith; Alli Oliver; Amory L. Koch; Laura E. Riddle; Cara Reiter; William E. Culp; Edward J. Caterson; Leon J. Nesti; Simon G. Talbot

doi:10.1016/j.aanat.2020.151587

A Yorkshire swine (Sus scrofa domesticus) model for nerve regeneration and ischemia based on the sciatic nerve and femoral artery

Sarah E. Kinsley, Stephen D. Fernicola, Marvin E. Dingle, Milfred S. Williams, Jody M. Richardson, Dennis Taylor, Jaira F. de Vasconcellos, Timothy R. Malone, Matthew R. Blattner, Jonathan K. Smith, Alli Oliver, Amory L. Koch, Laura E. Riddle, Cara Reiter, William E. Culp, Edward J. Caterson, Leon J. Nesti, Simon G. Talbot^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve injury models, a large animal model is essential to confirm the effects of nerve regeneration over the longer distances of regeneration required in humans. Swine have long been used as a large animal model for other surgical and biomedical studies. This paper represents a novel neurovascular injury model in the Sus scrofa domesticus swine (American Yorkshire pig). This paper will describe our experience and recommendations with pre-operative, operative and post-operative protocols and our refinements to produce an effective model.

Original language	English
Article number	151587
Journal	Annals of Anatomy
Volume	233
DOIs	https://doi.org/10.1016/j.aanat.2020.151587
State	Published - Jan 2021
Externally published	Yes

Keywords

American Yorkshire pig
Animal model
Nerve regeneration
Surgery

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Kinsley, S. E., Fernicola, S. D., Dingle, M. E., Williams, M. S., Richardson, J. M., Taylor, D., de Vasconcellos, J. F., Malone, T. R., Blattner, M. R., Smith, J. K., Oliver, A., Koch, A. L., Riddle, L. E., Reiter, C., Culp, W. E., Caterson, E. J., Nesti, L. J., & Talbot, S. G. (2021). A Yorkshire swine (Sus scrofa domesticus) model for nerve regeneration and ischemia based on the sciatic nerve and femoral artery. Annals of Anatomy, 233, Article 151587. https://doi.org/10.1016/j.aanat.2020.151587

@article{823cd80946384b90b6e79df14ff4e238,

title = "A Yorkshire swine (Sus scrofa domesticus) model for nerve regeneration and ischemia based on the sciatic nerve and femoral artery",

abstract = "Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve injury models, a large animal model is essential to confirm the effects of nerve regeneration over the longer distances of regeneration required in humans. Swine have long been used as a large animal model for other surgical and biomedical studies. This paper represents a novel neurovascular injury model in the Sus scrofa domesticus swine (American Yorkshire pig). This paper will describe our experience and recommendations with pre-operative, operative and post-operative protocols and our refinements to produce an effective model.",

keywords = "American Yorkshire pig, Animal model, Nerve regeneration, Surgery",

author = "Kinsley, {Sarah E.} and Fernicola, {Stephen D.} and Dingle, {Marvin E.} and Williams, {Milfred S.} and Richardson, {Jody M.} and Dennis Taylor and {de Vasconcellos}, {Jaira F.} and Malone, {Timothy R.} and Blattner, {Matthew R.} and Smith, {Jonathan K.} and Alli Oliver and Koch, {Amory L.} and Riddle, {Laura E.} and Cara Reiter and Culp, {William E.} and Caterson, {Edward J.} and Nesti, {Leon J.} and Talbot, {Simon G.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier GmbH",

year = "2021",

month = jan,

doi = "10.1016/j.aanat.2020.151587",

language = "English",

volume = "233",

journal = "Annals of Anatomy",

issn = "0940-9602",

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Kinsley, SE, Fernicola, SD, Dingle, ME, Williams, MS, Richardson, JM, Taylor, D, de Vasconcellos, JF, Malone, TR, Blattner, MR, Smith, JK, Oliver, A, Koch, AL, Riddle, LE, Reiter, C, Culp, WE, Caterson, EJ, Nesti, LJ & Talbot, SG 2021, 'A Yorkshire swine (Sus scrofa domesticus) model for nerve regeneration and ischemia based on the sciatic nerve and femoral artery', Annals of Anatomy, vol. 233, 151587. https://doi.org/10.1016/j.aanat.2020.151587

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AU - Kinsley, Sarah E.

AU - Fernicola, Stephen D.

AU - Dingle, Marvin E.

AU - Williams, Milfred S.

AU - Richardson, Jody M.

AU - Taylor, Dennis

AU - de Vasconcellos, Jaira F.

AU - Malone, Timothy R.

AU - Blattner, Matthew R.

AU - Smith, Jonathan K.

AU - Oliver, Alli

AU - Koch, Amory L.

AU - Riddle, Laura E.

AU - Reiter, Cara

AU - Culp, William E.

AU - Caterson, Edward J.

AU - Nesti, Leon J.

AU - Talbot, Simon G.

PY - 2021/1

Y1 - 2021/1

N2 - Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve injury models, a large animal model is essential to confirm the effects of nerve regeneration over the longer distances of regeneration required in humans. Swine have long been used as a large animal model for other surgical and biomedical studies. This paper represents a novel neurovascular injury model in the Sus scrofa domesticus swine (American Yorkshire pig). This paper will describe our experience and recommendations with pre-operative, operative and post-operative protocols and our refinements to produce an effective model.

AB - Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve injury models, a large animal model is essential to confirm the effects of nerve regeneration over the longer distances of regeneration required in humans. Swine have long been used as a large animal model for other surgical and biomedical studies. This paper represents a novel neurovascular injury model in the Sus scrofa domesticus swine (American Yorkshire pig). This paper will describe our experience and recommendations with pre-operative, operative and post-operative protocols and our refinements to produce an effective model.

KW - American Yorkshire pig

KW - Animal model

KW - Nerve regeneration

KW - Surgery

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VL - 233

JO - Annals of Anatomy

JF - Annals of Anatomy

M1 - 151587

ER -

A Yorkshire swine (Sus scrofa domesticus) model for nerve regeneration and ischemia based on the sciatic nerve and femoral artery

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Keywords

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