Accelerating HIV-1 vaccine efficacy trials

Dan H. Barouch*, Nelson L. Michael

*Corresponding author for this work

Research output: Contribution to journalComment/debate

14 Scopus citations


Despite major advances in HIV-1 therapeutics and prevention strategies, the development of a safe and effective prophylactic HIV-1 vaccine will likely be critical for ending the global HIV-1 epidemic. Yet only four HIV-1 vaccine concepts have been tested for clinical efficacy over the past 30 years. In this Commentary, we describe key hurdles facing the HIV-1 vaccine development field and outline strategies to accelerate efficacy evaluation of novel HIV-1 vaccine candidates.

Original languageEnglish
Pages (from-to)969-972
Number of pages4
Issue number5
StatePublished - 20 Nov 2014
Externally publishedYes


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