TY - JOUR
T1 - ACTH produces long-lasting recovery following partial extinction of an active avoidance response
AU - Ahlers, Stephen T.
AU - Richardson, Rick
AU - West, Chris
AU - Riccio, David C.
N1 - Funding Information:
J This research was supported by NIMH Grant MN37535 to D.C.R. Portions of this material were presented at the annual meeting for the Society of Neuroscience held in Washington, DC, November 1986. The assistance of Rondi Riester and Beth Heinbuch are gratefully acknowledged. Rick Richardson is now at the Department of Psychology, Princeton University. Reprint requests should be addressed to S. T. Ahlers now at the Environmental Medicine Department, Naval Medical Research Institute, Bethesda, MD 20814-5055.
PY - 1989/1
Y1 - 1989/1
N2 - Recent data suggest that ACTH administration produces recovery of an extinguished passive avoidance response at an unusually long injection-to-test interval. The present experiment sought to explore further the durability of recovery by examining the effect of ACTH following extinction of one-way active avoidance. Adult rats were injected with 16 IU ACTH, an equivalent volume of the ACTH vehicle gel, or saline 48 h after a previously learned active avoidance response was partially extinguished. Different groups from each treatment condition were tested 15 min, 24 h, or 7 days after injection. ACTH improved avoidance performance at all injection-to-test intervals relative to saline and vehicle gel injected controls. These data indicate that unlike reversal of other types of performance decrements, in which the effect of ACTH appears to be transient, administration of the hormone following an extinction treatment can produce enduring improvement of avoidance performance.
AB - Recent data suggest that ACTH administration produces recovery of an extinguished passive avoidance response at an unusually long injection-to-test interval. The present experiment sought to explore further the durability of recovery by examining the effect of ACTH following extinction of one-way active avoidance. Adult rats were injected with 16 IU ACTH, an equivalent volume of the ACTH vehicle gel, or saline 48 h after a previously learned active avoidance response was partially extinguished. Different groups from each treatment condition were tested 15 min, 24 h, or 7 days after injection. ACTH improved avoidance performance at all injection-to-test intervals relative to saline and vehicle gel injected controls. These data indicate that unlike reversal of other types of performance decrements, in which the effect of ACTH appears to be transient, administration of the hormone following an extinction treatment can produce enduring improvement of avoidance performance.
UR - http://www.scopus.com/inward/record.url?scp=0024546424&partnerID=8YFLogxK
U2 - 10.1016/S0163-1047(89)90712-7
DO - 10.1016/S0163-1047(89)90712-7
M3 - Article
C2 - 2539802
AN - SCOPUS:0024546424
SN - 0163-1047
VL - 51
SP - 102
EP - 107
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 1
ER -