Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees

Heather C. Yun; Michael W. Ellis; James H. Jorgensen

doi:10.1016/j.diagmicrobio.2007.06.023

Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees

Heather C. Yun^*, Michael W. Ellis, James H. Jorgensen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Ceftobiprole MICs at which 50% and 90% of isolates were inhibited (MIC₅₀ and MIC₉₀), determined by the Clinical and Laboratory Standards Institute broth microdilution method, were both 1 μg/mL (range, 0.5-1 μg/mL) against 143 community-associated methicillin-resistant Staphylococcus aureus isolates and 0.5 μg/mL (range, 0.25-0.5 μg/mL) with 29 methicillin-susceptible isolates recovered from military trainees during 2 prospective investigations.

Original language	English
Pages (from-to)	463-466
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	59
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2007.06.023
State	Published - Dec 2007
Externally published	Yes

Keywords

CA-MRSA
Ceftobiprole
MRSA
Military

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10.1016/j.diagmicrobio.2007.06.023

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title = "Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees",

abstract = "Ceftobiprole MICs at which 50% and 90% of isolates were inhibited (MIC50 and MIC90), determined by the Clinical and Laboratory Standards Institute broth microdilution method, were both 1 μg/mL (range, 0.5-1 μg/mL) against 143 community-associated methicillin-resistant Staphylococcus aureus isolates and 0.5 μg/mL (range, 0.25-0.5 μg/mL) with 29 methicillin-susceptible isolates recovered from military trainees during 2 prospective investigations.",

keywords = "CA-MRSA, Ceftobiprole, MRSA, Military",

author = "Yun, {Heather C.} and Ellis, {Michael W.} and Jorgensen, {James H.}",

note = "Funding Information: This study was supported in part by a grant from Johnson and Johnson Research and Pharmaceutical Development (Raritan, NJ), who also provided the ceftobiprole powder for the study. The authors thank M. Leticia McElmeel and Letitia Fulcher for their excellent technical assistance. They thank Jan E. Patterson and Cynthia C. Kelly who contributed with the molecular analysis of the CA-MRSA isolates. ",

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doi = "10.1016/j.diagmicrobio.2007.06.023",

language = "English",

volume = "59",

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journal = "Diagnostic Microbiology and Infectious Disease",

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T1 - Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees

AU - Yun, Heather C.

AU - Ellis, Michael W.

AU - Jorgensen, James H.

N1 - Funding Information: This study was supported in part by a grant from Johnson and Johnson Research and Pharmaceutical Development (Raritan, NJ), who also provided the ceftobiprole powder for the study. The authors thank M. Leticia McElmeel and Letitia Fulcher for their excellent technical assistance. They thank Jan E. Patterson and Cynthia C. Kelly who contributed with the molecular analysis of the CA-MRSA isolates.

PY - 2007/12

Y1 - 2007/12

N2 - Ceftobiprole MICs at which 50% and 90% of isolates were inhibited (MIC50 and MIC90), determined by the Clinical and Laboratory Standards Institute broth microdilution method, were both 1 μg/mL (range, 0.5-1 μg/mL) against 143 community-associated methicillin-resistant Staphylococcus aureus isolates and 0.5 μg/mL (range, 0.25-0.5 μg/mL) with 29 methicillin-susceptible isolates recovered from military trainees during 2 prospective investigations.

AB - Ceftobiprole MICs at which 50% and 90% of isolates were inhibited (MIC50 and MIC90), determined by the Clinical and Laboratory Standards Institute broth microdilution method, were both 1 μg/mL (range, 0.5-1 μg/mL) against 143 community-associated methicillin-resistant Staphylococcus aureus isolates and 0.5 μg/mL (range, 0.25-0.5 μg/mL) with 29 methicillin-susceptible isolates recovered from military trainees during 2 prospective investigations.

KW - CA-MRSA

KW - Ceftobiprole

KW - MRSA

KW - Military

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U2 - 10.1016/j.diagmicrobio.2007.06.023

DO - 10.1016/j.diagmicrobio.2007.06.023

M3 - Article

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IS - 4

ER -

Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees

Abstract

Keywords

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