Activity of the diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America

Roseanne A. Ressner; Matthew R. Moore; James H. Jorgensen

doi:10.1128/AAC.01387-07

Activity of the diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America

Roseanne A. Ressner, Matthew R. Moore, James H. Jorgensen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae. AR-709 was highly active, with a MIC₅₀ of 0.25 μg/ml, a MIC₉₀ of 0.5 μg/ml, and a range of ≤0.008 μg/ml to 1 μg/ml.

Original language	English
Pages (from-to)	1147-1149
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01387-07
State	Published - Mar 2008
Externally published	Yes

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title = "Activity of the diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America",

abstract = "Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae. AR-709 was highly active, with a MIC50 of 0.25 μg/ml, a MIC90 of 0.5 μg/ml, and a range of ≤0.008 μg/ml to 1 μg/ml.",

author = "Ressner, {Roseanne A.} and Moore, {Matthew R.} and Jorgensen, {James H.}",

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AB - Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae. AR-709 was highly active, with a MIC50 of 0.25 μg/ml, a MIC90 of 0.5 μg/ml, and a range of ≤0.008 μg/ml to 1 μg/ml.

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Activity of the diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America

Abstract

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