TY - JOUR
T1 - Administration of hepatitis a vaccine to a military population by needle and jet injector and with hepatitis b vaccine
AU - Charles, H. Hoke
AU - Egan, James E.
AU - Sjogren, Maria H.
AU - Sanchez, Jose
AU - Defraites, Robert F.
AU - Macarthy, Philip O.
AU - Binn, Leonard N.
AU - Rice, Robert
AU - Burke, Arlene
AU - Hill, Jeffrey
AU - Howard Kimes, M.
AU - Erikson, Loren
AU - Boscia, Jerome
AU - Moonsammy, George I.
AU - D' Hondt, Erik
AU - Bancroft, William H.
N1 - Funding Information:
Presented in part: 30th Interscience Conference on Antimicrobial Agents and Chemotherapy. September 1990 (abstracts 359 and 363). Written informed consent was obtained from each volunteer. Research was done in accord with Army Regulation 70-25. The protocol was approved by the Human Subjects Research Review Board of the Office of the Surgeon General of the US Army and by SmithKline Beecham Pharmaceuticals. The views expressed in this paper are the private views of the authors. They do not purport to be the views of the Department of the Army. the Department of Defense. or the United States Government. J.B., G.M., and E.D'H. are employees ofSmithKline Beecham Biologicals. Financial support: US Army Medical Material Development Activity, Fort Detrick. Reprints or correspondence: Dr. Charles H. Hoke, Jr., Dept. of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC 20307-5100. * Present affiliations: Ogden Biosciences, Rockville. Maryland (R.R.); Walter Reed Army Medical Center, Washington, DC (M.H,S.); US Army Medical Research and Material Development Command (Provisional), Fort Detrick (W.H.B.); Colorado Springs. Colorado (A.B.); Louisiana State University Medical School, New Orleans (J.H.); Johns Hopkins University. Baltimore (L. E.).
PY - 1995/3
Y1 - 1995/3
N2 - Military personnel are an important target population for hepatitis A immunization. Soldiers are often given vaccines by jet injector and may be required to receive multiple vaccines at one time. Formalin-inactivated hepatitis A vaccine containing 360 ELISA units of antigen was evaluated at Fort Campbell. Volunteers received vaccine at 0, 1, and 6 months as follows: group 1, hepatitis A vaccine by needle; group 2, hepatitis A vaccine by jet injector; group 3, hepatitis B vaccine by needle; and group 4, both hepatitis vaccines by needle in separate arms. Immune response and reactogenicity were evaluated. After two doses, recipients of vaccine administered by jet injector had a higher prevalence of antibody than those who received vaccine by needle (93% vs. 79%). By the 8th month, the vaccine was 100% immunogenic by either route or with hepatitis B vaccine. No interaction between hepatitis A and B vaccines was detected.
AB - Military personnel are an important target population for hepatitis A immunization. Soldiers are often given vaccines by jet injector and may be required to receive multiple vaccines at one time. Formalin-inactivated hepatitis A vaccine containing 360 ELISA units of antigen was evaluated at Fort Campbell. Volunteers received vaccine at 0, 1, and 6 months as follows: group 1, hepatitis A vaccine by needle; group 2, hepatitis A vaccine by jet injector; group 3, hepatitis B vaccine by needle; and group 4, both hepatitis vaccines by needle in separate arms. Immune response and reactogenicity were evaluated. After two doses, recipients of vaccine administered by jet injector had a higher prevalence of antibody than those who received vaccine by needle (93% vs. 79%). By the 8th month, the vaccine was 100% immunogenic by either route or with hepatitis B vaccine. No interaction between hepatitis A and B vaccines was detected.
UR - https://www.scopus.com/pages/publications/0028919224
U2 - 10.1093/infdis/171.Supplement_1.S53
DO - 10.1093/infdis/171.Supplement_1.S53
M3 - Article
C2 - 7876650
AN - SCOPUS:0028919224
SN - 0022-1899
VL - 171
SP - S53-S60
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -