Aflibercept in pediatric solid tumors: Moving beyond the trap

Cindy H. Chau, William D. Figg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Angiogenesis plays a pivotal role in the growth and metastasis of adult and pediatric solid tumors. Clinical investigation of angiogenesis inhibitors is currently under way for childhood cancers. While the pediatric study of aflibercept provides a proof-of-principle, challenges remain in developing clinical endpoints and biomarkers of angiogenesis for pediatric trials.

Original languageEnglish
Pages (from-to)4868-4871
Number of pages4
JournalClinical Cancer Research
Issue number18
StatePublished - 15 Sep 2012
Externally publishedYes


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