Aging and neoteny in the B lineage

Doron Melamed*, David W. Scott

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Aging and the physiologic decline of tissues and cells were once thought to be irreversible. However, recent studies suggest that various tissues, especially parts of the hematopoietic system, can be rejuvenated. Here we review potential mechanisms for this process and how they may be used to reverse age-related disorders and aging in general. We propose the novel hypothesis that altering the homeostatic process during cellular depletion can reverse aging in the hematopoietic system.

Original languageEnglish
Pages (from-to)4143-4149
Number of pages7
Issue number20
StatePublished - 15 Nov 2012
Externally publishedYes


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