@article{d23b27f185f04cdcb467b1cf2c2feb84,
title = "Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates",
abstract = "Memory T cells promote allograft rejection particularly in co-stimulation blockade-based immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept (lymphocyte function-associated antigen-3-Ig; LFA -3-Ig) selectively eliminates memory T cells and, when combined with a co-stimulation blockade-based regimen using cytotoxic T lymphocyte antigen-4 (CTLA-4)-Ig, a CD80- and CD86-specific fusion protein, prevents renal allograft rejection and alloantibody formation in nonhuman primates. These results support the immediate translation of a regimen for the prevention of allograft rejection without the use of calcineurin inhibitors, steroids or pan-T cell depletion.",
author = "Weaver, {Tim A.} and Charafeddine, {Ali H.} and Avinash Agarwal and Turner, {Alexandra P.} and Maria Russell and Leopardi, {Frank V.} and Kampen, {Robert L.} and Linda Stempora and Mingqing Song and Larsen, {Christian P.} and Kirk, {Allan D.}",
note = "Funding Information: This study was funded in part by the Division of Intramural Research, National Institute of Diabetes, Digestive and Kidney Disease, NIH (Z01 DK062007-06). Salary support for T.A.W. was provided by the Howard Hughes Medical Institute through the NIH Research Scholars Program. A.D.K. is supported by the National Institutes of Health (1U01AI079223-01A1), the Georgia Research Alliance and the McKelvey Foundation. We gratefully acknowledge the expert assistance of J. Bacher and the staff of the NIH Veterinary Pathology Department.",
year = "2009",
month = jul,
doi = "10.1038/nm.1993",
language = "English",
volume = "15",
pages = "746--749",
journal = "Nature Medicine",
issn = "1078-8956",
number = "7",
}