Alleles Lost and Gained in Malignant Cells

Pei Jer Chen; Shiou Hwei Yeh; Ding Shinn Chen; Harry B. Burke; Stanley R. Hamilton; Jin Jen; Bert Vogelstein

doi:10.1056/NEJM199412083312314

Alleles Lost and Gained in Malignant Cells

Pei Jer Chen, Shiou Hwei Yeh, Ding Shinn Chen, Harry B. Burke, Stanley R. Hamilton, Jin Jen, Bert Vogelstein

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

Abstract

To the Editor: In their study of the correlation between the allelic loss of chromosome 18q and survival among patients with colorectal cancer (July 28 issue),¹ Jen et al. used microsatellite polymorphisms to distinguish between two alleles in tumor DNA. A “relative intensity of the two alleles in the tumor DNA [that] differed from the relative intensity in the non-neoplastic tissue DNA by a factor of at least 1.5” was used as the criterion for loss of heterozygosity.² However, this criterion is not stringent enough to support the loss of heterozygosity in some cases of liver cancer. We used 12…

Original language	English
Pages (from-to)	1591-1592
Number of pages	2
Journal	New England Journal of Medicine
Volume	331
Issue number	23
DOIs	https://doi.org/10.1056/NEJM199412083312314
State	Published - 8 Dec 1994
Externally published	Yes

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title = "Alleles Lost and Gained in Malignant Cells",

abstract = "To the Editor: In their study of the correlation between the allelic loss of chromosome 18q and survival among patients with colorectal cancer (July 28 issue),1 Jen et al. used microsatellite polymorphisms to distinguish between two alleles in tumor DNA. A “relative intensity of the two alleles in the tumor DNA [that] differed from the relative intensity in the non-neoplastic tissue DNA by a factor of at least 1.5” was used as the criterion for loss of heterozygosity.2 However, this criterion is not stringent enough to support the loss of heterozygosity in some cases of liver cancer. We used 12…",

author = "Chen, {Pei Jer} and Yeh, {Shiou Hwei} and Chen, {Ding Shinn} and Burke, {Harry B.} and Hamilton, {Stanley R.} and Jin Jen and Bert Vogelstein",

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TY - JOUR

T1 - Alleles Lost and Gained in Malignant Cells

AU - Chen, Pei Jer

AU - Yeh, Shiou Hwei

AU - Chen, Ding Shinn

AU - Burke, Harry B.

AU - Hamilton, Stanley R.

AU - Jen, Jin

AU - Vogelstein, Bert

PY - 1994/12/8

Y1 - 1994/12/8

N2 - To the Editor: In their study of the correlation between the allelic loss of chromosome 18q and survival among patients with colorectal cancer (July 28 issue),1 Jen et al. used microsatellite polymorphisms to distinguish between two alleles in tumor DNA. A “relative intensity of the two alleles in the tumor DNA [that] differed from the relative intensity in the non-neoplastic tissue DNA by a factor of at least 1.5” was used as the criterion for loss of heterozygosity.2 However, this criterion is not stringent enough to support the loss of heterozygosity in some cases of liver cancer. We used 12…

AB - To the Editor: In their study of the correlation between the allelic loss of chromosome 18q and survival among patients with colorectal cancer (July 28 issue),1 Jen et al. used microsatellite polymorphisms to distinguish between two alleles in tumor DNA. A “relative intensity of the two alleles in the tumor DNA [that] differed from the relative intensity in the non-neoplastic tissue DNA by a factor of at least 1.5” was used as the criterion for loss of heterozygosity.2 However, this criterion is not stringent enough to support the loss of heterozygosity in some cases of liver cancer. We used 12…

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U2 - 10.1056/NEJM199412083312314

DO - 10.1056/NEJM199412083312314

M3 - Letter

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AN - SCOPUS:0028072843

SN - 0028-4793

VL - 331

SP - 1591

EP - 1592

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 23

ER -

Alleles Lost and Gained in Malignant Cells

Abstract

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