@article{06a75b4fbf5e4ee0bcd391cd9dd23928,
title = "Allogeneic interactions in the immune response and tolerance. I. The allogeneic effect in unprimed rats and mice",
abstract = "Normal rats and mice showed a significant increase in trinitrophenyl-specific plaque-forming cells following the administration of immunocompetent allogeneic spleen cells. The {"}response{"} was maximal at 4-5 days and decreased to background levels by 7-12 days. Induction of a graft-versus-host reaction produced a greater increment in direct trinitrophenyl plaque-forming cells than was found with a host-versus-graft, although the kinetics were identical in both cases. The increase in the number of plaque-forming cells was derived from the host in the graft-versus-host and at least in part from the donor in the host-versus-graft. This effect was not restricted to rats, as it was demonstrable in allogeneic combinations in normal mice and with a xenogeneic (rat → mouse) interaction. The trinitrophenyl specificity detected herein was attributed to prior sensitization with crossreacting environmental antigens. The results suggest that foreign lymphoid cells are able to trigger these cells to differentiate and proliferate into plaque-forming cells.",
author = "Ornellas, {Eugene P.} and Scott, {David W.}",
note = "Funding Information: The initiation of a graft-versus-host (GVH) 2 reaction in hapten-carrier conjugate primed guinea pigs and mice by the transfer of immunocompetent allogeneic lymphoid cells results in the increased synthesis of specific antihapten and anti-carrier antibody in the absence of further specific antigenic challenge (l-4). Transfer of allogeneic cells to primed hosts also markedly enhances an antihapten response to secondary challenge when the hapten is coupled to an unrelated carrier (1-4). This phenomenon, the “allogeneic effect” (l), requires a transient GVH reaction and priming of the host prior to the administration of allogeneic cells; previous attempts to demonstrate an augmented primary response by the prior administration of allogeneic lymphoid cells have failed (1). In fact, it is well established that animals undergoing a GVH reaction usually show marked suppression 1 Supported in part by US Public Health Service, grant AI-10716. * Abbreviations used in this paper : B cells, bone marrow-derived lymphoid cells ; BN, Brown",
year = "1974",
month = mar,
day = "30",
doi = "10.1016/0008-8749(74)90011-2",
language = "English",
volume = "11",
pages = "108--115",
journal = "Cellular Immunology",
issn = "0008-8749",
number = "1-3",
}